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Systematic (IUPAC) name
10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one O-[2-dimethylamino)ethyl]oxime
Clinical data
Routes of
Legal status
Legal status
  • ℞ (Prescription only)
CAS Number 4985-15-3
ATC code none
PubChem CID 21087
ChemSpider 19832
Chemical data
Formula C19H22N2O
Molar mass 294.39 g/mol[[Script error: No such module "String".]]
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Noxiptiline (Agedal, Elronon, Nogedal), also known as noxiptyline and dibenzoxine, is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1970s for the treatment of depression.[1][2][3] It has imipramine-like effects,[4] acting as a serotonin and norepinephrine reuptake inhibitor, among other properties.[5][6] Of the TCAs, noxiptiline has been shown to be one of the most effective, rivaling amitriptyline in clinical efficacy.[7][8]

See also


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  1. Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 753. ISBN 3-88763-075-0.  More than one of |pages= and |page= specified (help)
  2. Aronson, Jeffrey Kenneth (2008). Meyler's Side Effects of Psychiatric Drugs (Meylers Side Effects). Amsterdam: Elsevier Science. p. 34. ISBN 0-444-53266-8.  More than one of |pages= and |page= specified (help)
  3. Dictionary of organic compounds. London: Chapman & Hall. 1996. p. 4868. ISBN 0-412-54090-8.  More than one of |pages= and |page= specified (help)
  4. Mutschler, Ernst (1995). Drug actions: basic principles and theraputic aspects. Stuttgart, German: Medpharm Scientific Pub. p. 127. ISBN 0-8493-7774-9.  More than one of |pages= and |page= specified (help)
  5. Ernst Jucker; S. Ren; Soudijn, W.; Wijngaarden, I. van; M. Kumari; D. Poyner; M. Bushfield; H. Horikoshi; Fujiwara, Tamenari (2000). Progress in Drug Research, Volume 54 (Progress in Drug Research). Boston: Birkhauser. p. 81. ISBN 3-7643-6113-1.  More than one of |pages= and |page= specified (help)
  6. Barth N, Manns M, Muscholl E (1975). "Arrhythmias and inhibition of noradrenaline uptake caused by tricyclic antidepressants and chlorpromazine on the isolated perfused rabbit heart". Naunyn-Schmiedeberg's Archives of Pharmacology. 288 (2-3): 215–31. 
  7. Beresewicz M, Bidzińska E, Koszewska I, Puzyński S (1991). "[Results of using tricyclic antidepressive drugs in the treatment of endogenous depression (comparative analysis of 7 drugs)]". Psychiatria Polska (in Polish). 25 (3-4): 13–8. PMID 1687987. 
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