Difference between revisions of "Ifenprodil"

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Ifenprodil
File:Ifenprodil.svg
IUPAC name
4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol
style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers
CAS number 245-491-4
PubChem 3689
SMILES Script error: No such module "collapsible list".
style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula C21H27NO2
Molar mass 325.445
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Ifenprodil is a selective inhibitor of the NMDA receptor.[1]

NMDA receptors are multimeric ionotropic glutamate receptors composed of four subunits. NR1 is obligate for functional expression. Other subunits include NR2A, NR2B, and the more recently discovered NR3 subunits. Ifenprodil selectively blocks NMDA receptors containing the NR2B subunit.

References

  1. ↑ Reynolds IJ, Miller RJ (1989). "Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines". Mol. Pharmacol. 36 (5): 758–65. PMID 2555674. 
Peripheral vasodilators (C04)
2-amino-1-phenylethanol derivatives
Imidazoline derivatives/
Alpha blockers
Niacin and derivatives
Purine derivatives
Ergot alkaloids
Other peripheral vasodilators


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