Bufexamac

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Bufexamac
File:Bufexamac.png
Systematic (IUPAC) name
2-(4-butoxyphenyl)-N-hydroxyacetamide
Clinical data
Routes of
administration		 Topical, rectal
Legal status
Legal status
  • OTC
Pharmacokinetic data
Excretion Renal
Identifiers
CAS Number 2438-72-4
ATC code M01AB17 (WHO) M02AA09
PubChem CID 2466
Chemical data
Formula C12H17NO3
Molar mass 223.268 g/mol[[Script error: No such module "String".]]
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Bufexamac is a drug used as an anti-inflamatory agent on the skin, as well as rectally. Common brand names include Paraderm and Parfenac.

Indications

Ointments and lotions containing bufexamac are used for the treatment of subacute and chronic eczema of the skin, including atopic eczema, as well as sunburn and other minor burns[citation needed], and itching. Suppositories containing bufexamac in combination with local anaesthetics are used against haemorrhoids.[1]

Pharmacology

Bufexamac is thought to act by inhibiting the enzyme cyclooxygenase, which would make it an non-steroidal anti-inflammatory drug. Evidence on the mechanism of action is scarce.[2]

Side-effects

Bufexamac can cause severe contact dermatitis which is often hard to distinguish from the initial condition.[3] As a consequence, the European Medicines Agency recommended to withdraw the marketing approval in April 2010.[4]

References

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Pyrazolidine/Butylpyrazolidines
Acetic acid derivatives
and related substances
Oxicams
Propionic acid derivatives
Fenamates
Coxibs
Other

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

Topical products for joint and muscular pain (M02)
Anti-inflammatory preparations,
non-steroids
Acetic acid derivatives
Other
Capsaicin derivatives
Other
de:Bufexamac

fr:Bufexamac ja:ブフェキサマク

pt:Bufexamaco
  1. ↑ Dinnendahl, V, Fricke, U, ed. (2010). Arzneistoff-Profile (in German) (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-98-46-3.  Text "volume2" ignored (help)
  2. ↑ Gloor, Max; Thoma, Karl; Fluhr, Joachim (2000). Dermatologische Externatherapie: Unter besonderer Berücksichtigung der Magistralrezeptur (in German). Springer. p. 349. ISBN 3540671749. 
  3. ↑ "Bufexamac: Ein Ekzemtherapeutikum, das selbst häufig allergische Kontaktekzeme hervorruft". Deutsches Ärzteblatt (in German) (47). 2000. 
  4. ↑ "European Medicines Agency recommends revocation of marketing authorisations for bufexamac" (PDF). European Medicines Agency. 22-04-2010.  Check date values in: |date= (help)
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