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Systematic (IUPAC) name
2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
Legal status
Legal status
  • UK: POM (Prescription only)
CAS Number 53164-05-9
ATC code M01AB11 (WHO)
PubChem CID 1981
Chemical data
Formula C21H18ClNO6
Molar mass 415.82372 g/mol[[Script error: No such module "String".]]
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Acemetacin is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. It is manufactured by Merck under the tradename Emflex, and is available in the UK as a prescription-only drug. Other brand names for acemetacin include Rheutrop (Austria), Acemetadoc, Acephlogont, Azeat, Rantudil (Germany), Gamespir (Greece), Oldan, Reudol (Spain), Tilur (Switzerland).

Acemetacin, a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of acemetacin is that it reduces gastric damage when compared to indometacin.


it:Acemetacina pl:Acemetacyna pt:Acemetacina vi:Acemetacin