Indoprofen
From Self-sufficiency
File:Indoprofen.svg | |
Systematic (IUPAC) name | |
---|---|
2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl) phenyl]propanoic acid | |
Clinical data | |
Routes of administration | Oral |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | High (rapid and complete absorption) |
Metabolism | Glucuronidation |
Biological half-life | 2.3 hours |
Excretion | Renal |
Identifiers | |
CAS Number | 31842-01-0 |
ATC code | M01AE10 (WHO) |
PubChem | CID 3718 |
Chemical data | |
Formula | C17H15NO3 |
Molar mass | 281.306 g/mol[[Script error: No such module "String".]] |
Indoprofen is a non-steroidal anti-inflammatory drug. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.[1]
A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.[1][2]
References
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45px | This drug article relating to the musculoskeletal system is a stub. You can help ssf by expanding it. |
- ↑ 1.0 1.1 Frazin, Natalie (March 9, 2005). "Pain Reliever May Provide Clues for Treating Spinal Muscular Atrophy". United States National Institute of Neurological Disorders and Stroke. Retrieved 2007-10-06.
- ↑ Lunn MR, Root DE, Martino AM; et al. (2004). "Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism". Chem Biol. 11 (11): 1489–93. doi:10.1016/j.chembiol.2004.08.024. PMID 15555999.
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