Loxoprofen

Loxoprofen

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Systematic (IUPAC) name
(RS)-2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
Clinical data
Routes of administration	Oral, transdermal
Legal status
Legal status	Red Stripe (Brazil)
Pharmacokinetic data
Protein binding	97%
Metabolism	Hepatic glucuronidation
Biological half-life	75 minutes
Excretion	Renal
Identifiers
CAS Number	68767-14-6
ATC code	M01AE (WHO)
PubChem	CID 3965
Chemical data
Formula	C15H18O3
Molar mass	246.302 g/mol 304.314 g/mol (sodium salt)[[]]

Loxoprofen (INN) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is marketed in Brazil, Mexico and Japan by Sankyo as its sodium salt, loxoprofen sodium, under the trade name Loxonin, Argentina as Oxeno and in India as Loxomac . It is available in these countries for oral administration, and a transdermal preparation was approved for sale in Japan on January 2006.

Pharmacokinetics

Loxoprofen is a prodrug. It is quickly converted to its active trans-alcohol metabolite following oral administration, and reaches its peak plasma concentration within 30 to 50 minutes.

Mechanism of action

As most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid.

Interactions

Loxoprofen should not be administered concomitantly with second-generation quinolone antibiotics such as ciprofloxacin and norfloxacin, as it increases their inhibition of GABA and this may cause seizures. It may also increase the plasma concentration of warfarin, methotrexate, sulfonylurea derivatives and lithium salts, so care should be taken when loxoprofen is administered to patients taking any of these drugs.

References

bs:Loksoprofen pt:Loxoprofeno