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  • Halothane
    | metabolism = [[Liver|Hepatic]] ([[CYP2E1]]<ref>[http://redpoll.pharmacy.ualberta.ca/dr ...ly, halothane is not an [[ether]]. Attempts to find anaesthetics with less metabolism led to [[halogenated ethers]] such as [[enflurane]] and [[isoflurane]]. The
    6 KB (845 words) - 11:06, 20 September 2010
  • Ivermectin
    | metabolism = liver; CYP450
    10 KB (1,292 words) - 16:41, 27 September 2010
  • Quinine
    | metabolism = [[Liver|Hepatic]] (mostly [[CYP3A4]] and [[CYP2C19]]-mediated)
    27 KB (3,844 words) - 16:41, 27 September 2010
  • Mefloquine
    | metabolism = Extensively hepatic; main metabolite is inactive
    13 KB (1,807 words) - 16:41, 27 September 2010
  • Glibenclamide
    | metabolism = [[Liver|Hepatic]] [[hydroxylation]] ([[CYP2C9]]-mediated)
    6 KB (743 words) - 21:12, 31 August 2010
  • Spectinomycin
    | metabolism =
    3 KB (327 words) - 16:41, 27 September 2010
  • Bupivacaine
    | metabolism = [[hepatic]]
    6 KB (809 words) - 15:05, 6 July 2010
  • Lidocaine
    | metabolism = [[Liver|Hepatic]], 90% [[CYP1A2]]-mediated
    15 KB (2,006 words) - 16:41, 27 September 2010
  • Allopurinol
    | metabolism = hepatic (80% oxypurinol, 10% allopurinol ribosides) ...resulting in the production of [[uric acid]], the product of human purine metabolism.<ref name="pmid16507884"/> In addition to blocking uric acid production, in
    7 KB (864 words) - 16:41, 27 September 2010
  • Chloroquine
    | metabolism = Liver ...s, which the parasite requires to construct its own protein and for energy metabolism. Digestion is carried out in a vacuole of the parasite cell.
    16 KB (2,187 words) - 16:41, 27 September 2010
  • Chlorphenamine
    | metabolism = [[Liver|Hepatic]] ([[CYP2D6]])
    6 KB (745 words) - 15:05, 6 July 2010
  • Dexamethasone
    | metabolism = [[hepatic]]
    18 KB (2,498 words) - 16:41, 27 September 2010
  • Prednisolone
    | metabolism =
    7 KB (872 words) - 16:41, 27 September 2010
  • Acetylcysteine
    | metabolism = [[hepatic]] ...ism is through scavenging of [[acetaldehyde]], a toxic intermediate in the metabolism of ethanol.<ref>Fawkes, SW [http://www.ceri.com/alcohol.htm CERI: Living wi
    28 KB (3,682 words) - 16:42, 27 September 2010
  • Deferoxamine
    | metabolism = ?
    5 KB (714 words) - 20:14, 21 September 2010
  • Naloxone
    | bioavailability = 2% (Oral, 90% absorption but high [[first-pass metabolism]]) | metabolism = [[Liver]]
    33 KB (4,541 words) - 10:57, 17 June 2016
  • Penicillamine
    | metabolism = Hepatic * In [[Wilson's disease]], a rare genetic disorder of [[copper]] metabolism, penicillamine treatment relies on its binding to accumulated copper and el
    5 KB (570 words) - 20:14, 21 September 2010
  • Carbamazepine
    | metabolism = [[Liver|Hepatic]]—by [[CYP3A4]], to active [[epoxide]] form (carbamazep ...channel blocker]]s.<ref name=Lexi-Comp/> Carbamazepine also increases the metabolism of the hormones in [[birth control pill]]s and can reduce their effectivene
    16 KB (2,164 words) - 16:42, 27 September 2010
  • Phenobarbital
    | metabolism = [[Liver|Hepatic]] (mostly [[CYP2C19]]) Phenobarbital was used to treat [[neonatal jaundice]] by increasing liver metabolism and thus lowering [[bilirubin]] levels. In the 1950s, [[phototherapy]] was
    20 KB (2,657 words) - 16:42, 27 September 2010
  • Phenytoin
    | metabolism = [[hepatic]]
    12 KB (1,686 words) - 16:42, 27 September 2010
  • Albendazole
    | metabolism = oxidation of sulfur atom to [[sulfoxide]], the active metabolite
    10 KB (1,261 words) - 13:28, 4 September 2010
  • Levamisole
    | metabolism = [[Liver|Hepatic]]
    10 KB (1,350 words) - 16:42, 27 September 2010
  • Mebendazole
    | metabolism = Hepatic
    5 KB (619 words) - 16:42, 27 September 2010
  • Niclosamide
    ...8 | Cl=2 | N=2 | O=4| molecular_weight = 327.119 g/mol| bioavailability= | metabolism = | elimination_half-life=| excretion = | pregnancy_category = | legal_sta
    2 KB (307 words) - 11:05, 20 September 2010
  • Praziquantel
    | metabolism = hepatic ...als#Imidazole_and_triazole_antifungals|azole]] antifungals will affect the metabolism of praziquantel.
    12 KB (1,580 words) - 16:42, 27 September 2010
  • Clindamycin
    |metabolism = [[Liver|Hepatic]]
    25 KB (3,261 words) - 14:17, 11 September 2010
  • Chloramphenicol
    | metabolism = [[Liver|Hepatic]] Chloramphenicol increases the absorption of [[Human iron metabolism|iron]].<ref>{{cite encyclopedia |encyclopedia= Pill Book, The |title= Iron
    29 KB (3,876 words) - 16:42, 27 September 2010
  • Doxycycline
    | metabolism = hepatic,minimally
    20 KB (2,578 words) - 16:43, 27 September 2010
  • Erythromycin
    | metabolism = liver (under 5% excreted unchanged) === Metabolism ===
    19 KB (2,731 words) - 17:52, 18 September 2010
  • Gentamicin
    | metabolism = ...ndoval R, Molitoris BA: Gentamicin Inhibits Renal Protein and Phospholipid Metabolism in Rats: Implications Involving Intracellular Trafficking. J Am Soc Nephrol
    9 KB (1,199 words) - 16:43, 27 September 2010
  • Metronidazole
    | metabolism = [[Hepatic]] ...ents known to produce disulfiram-like reaction: effects on hepatic ethanol metabolism and brain monoamines |journal=International Journal of Toxicology |volume=2
    19 KB (2,528 words) - 16:43, 27 September 2010
  • Nitrofurantoin
    | metabolism = liver (75%) ...phys Acta | volume=402 | pages=142&ndash;49 }}</ref> respiration, pyruvate metabolism and other macromolecules within the cell. It is not known which of the act
    12 KB (1,576 words) - 16:43, 27 September 2010
  • Trimethoprim
    |metabolism = [[hepatic]]
    8 KB (1,056 words) - 20:12, 10 September 2010
  • Sulfadiazine
    | metabolism = ?
    2 KB (194 words) - 13:11, 20 September 2010
  • Vancomycin
    | metabolism = Excreted unchanged
    31 KB (4,198 words) - 16:43, 27 September 2010
  • Clofazimine
    | metabolism = ==Metabolism==
    12 KB (1,651 words) - 16:43, 27 September 2010
  • Dapsone
    | metabolism = [[Liver|Hepatic]] (mostly [[CYP2E1]]-mediated)
    15 KB (2,087 words) - 16:43, 27 September 2010
  • Rifampicin
    |metabolism = [[Liver|Hepatic]] and intestinal wall ...P450]] enzymes (such as [[CYP2C9]] and [[CYP3A4]]), increasing the rate of metabolism of many other drugs that are cleared by the liver through these enzymes. As
    18 KB (2,471 words) - 16:43, 27 September 2010
  • Ethambutol
    | metabolism = [[Liver]]
    3 KB (384 words) - 16:43, 27 September 2010
  • Isoniazid
    | metabolism = liver; CYP450: 2C19, 3A4 inhibitor ==Metabolism==
    12 KB (1,566 words) - 16:43, 27 September 2010
  • Pyrazinamide
    | metabolism = [[Liver|Hepatic]]
    12 KB (1,557 words) - 16:44, 27 September 2010
  • Streptomycin
    | metabolism =
    9 KB (1,069 words) - 15:06, 6 July 2010
  • Amikacin
    | metabolism =
    4 KB (498 words) - 16:44, 27 September 2010
  • Capreomycin
    | metabolism =
    2 KB (185 words) - 16:44, 27 September 2010
  • Cycloserine
    | metabolism = Hepatic
    5 KB (602 words) - 16:44, 27 September 2010
  • Ethionamide
    ...bioavailability = | protein_bound = Approximately 30% bound to proteins. | metabolism = | elimination_half-life = 2 to 3 hours | pregnancy_category = | legal_sta
    2 KB (278 words) - 16:44, 27 September 2010
  • Kanamycin
    | metabolism = Unknown
    4 KB (503 words) - 16:44, 27 September 2010
  • Clotrimazole
    | metabolism = [[hepatic]] ...-demethylase|cytochrome P450 oxidase]] and may alter the [[drug metabolism|metabolism]] of other drugs.
    4 KB (525 words) - 11:13, 20 September 2010
  • Fluconazole
    | metabolism = Hepatic 11% ...azole follows zero order kinetics, and only 10% of elimination is due to [[metabolism]], the remainder is excreted in urine and sweat. Patients with impaired ren
    11 KB (1,533 words) - 16:44, 27 September 2010
  • Griseofulvin
    | metabolism = [[Liver|Hepatic]] [[demethylation]] and [[glucuronidation]]
    5 KB (678 words) - 14:58, 19 September 2010
  • Nystatin
    | metabolism = ?
    7 KB (941 words) - 16:44, 27 September 2010
  • Amphotericin B
    | metabolism = renal ...b. "Amphotericin B and Its New Derivatives - Mode of Action." Current Drug Metabolism. 10.5 (2009): 459-69. Print.</ref> The actual mechanism of action may be mo
    13 KB (1,785 words) - 16:44, 27 September 2010
  • Flucytosine
    | metabolism = Minimal, in the [[Gastrointestinal tract|GI tract]]
    10 KB (1,394 words) - 16:44, 27 September 2010
  • Aciclovir
    | metabolism = Viral thymidine kinase ...tion of further activity of DNA polymerase. Acyclo-GTP is fairly rapidly [[metabolism|metabolised]] within the cell, possibly by cellular [[phosphatase]]s.
    14 KB (1,878 words) - 16:44, 27 September 2010
  • Abacavir
    |metabolism=[[Liver|Hepatic]]
    8 KB (1,124 words) - 16:44, 27 September 2010
  • Didanosine
    | metabolism =
    9 KB (1,239 words) - 16:44, 27 September 2010
  • Emtricitabine
    | metabolism = [[Liver|Hepatic]] [[oxidation]] and [[glucuronidation]]<br>[[Cytochrome P
    5 KB (667 words) - 16:44, 27 September 2010
  • Lamivudine
    | metabolism =
    9 KB (1,248 words) - 16:44, 27 September 2010
  • Stavudine
    | metabolism = Renal elimination (ca.40%)
    4 KB (574 words) - 16:44, 27 September 2010
  • Tenofovir
    | metabolism =
    6 KB (871 words) - 16:45, 27 September 2010
  • Efavirenz
    | metabolism = [[Liver|Hepatic]] ([[CYP3A4]] and [[CYP2B6]]-mediated) ...nthard HF, Bleiber G, Krause M. Efavirenz intoxication due to slow hepatic metabolism. ''Clinical Infectious Diseases''. 2005 Feb 1;40(3):e22-3. PMID 15668854</r
    10 KB (1,441 words) - 16:45, 27 September 2010
  • Nevirapine
    |metabolism = [[Liver|Hepatic]]
    15 KB (2,090 words) - 16:45, 27 September 2010
  • Indinavir
    | metabolism = [[Liver|Hepatic]] via [[CYP3A4]]
    3 KB (320 words) - 15:07, 6 July 2010
  • Lopinavir
    | metabolism = [[Liver|Hepatic]]
    8 KB (1,109 words) - 16:45, 27 September 2010
  • Ritonavir
    | metabolism = * [[amiodarone]] - decreased metabolism, possible toxicity
    9 KB (1,233 words) - 15:07, 6 July 2010
  • Saquinavir
    | metabolism =
    5 KB (717 words) - 15:07, 6 July 2010
  • Nelfinavir
    | metabolism = Hepatic metabolism by CYP450 incl. CYP3A4
    8 KB (1,160 words) - 16:45, 27 September 2010
  • Ribavirin
    | metabolism = Metabolized to 5'phosphates, de-riboside, and deriboside carboxylic acid ...es [[purine]] [[RNA]] [[nucleotide]]s. In this form it interferes with RNA metabolism required for viral replication. How it exactly affects viral replication is
    23 KB (3,222 words) - 16:45, 27 September 2010
  • Diloxanide furoate
    | metabolism = [[hydrolysis|Hydrolyzed]] to furoic acid and diloxanide, which und
    3 KB (375 words) - 15:07, 6 July 2010
  • Codeine
    | metabolism = [[Liver|Hepatic]], via [[CYP2D6]] (Cytochrome P450 2D6)<ref>{{Cite journa ...gth ranges from 8 to 12 percent of morphine in most people; differences in metabolism can change this figure as can other medications, depending on its route of
    40 KB (5,581 words) - 16:45, 27 September 2010
  • Sodium nitrite
    ...of [[nitric oxide]]'s importance to human metabolism and human endogenous metabolism of nitrite.
    21 KB (3,046 words) - 16:45, 27 September 2010
  • Atropine
    | metabolism = 50% [[hydrolyse]]d to [[tropine]] and [[tropic acid]]
    16 KB (2,198 words) - 16:46, 27 September 2010
  • 4-Aminosalicylic acid
    | metabolism = [[Liver|Hepatic]]
    7 KB (879 words) - 16:46, 27 September 2010
  • Ketamine
    ...rms to N-demethylation of ketamine in human liver microsomes |journal=Drug Metabolism and Disposition |volume=30 |issue=7 |pages=853–8 |year=2002 |month=July | ...s those in humans to start with. It is because of this higher base rate of metabolism that ketamine causes over-excitement in rats at doses below those at which
    69 KB (9,697 words) - 21:01, 24 September 2010
  • Ciprofloxacin
    | metabolism = Hepatic, including [[CYP1A2]] ...floxacin being an inhibitor of human cytochrome P450 1A2 (CYP1A2) mediated metabolism. The new warning stated: <blockquote>"Coadministration of ciprofloxacin wit
    88 KB (11,930 words) - 16:46, 27 September 2010
  • Sodium thiopental
    | metabolism = ==Metabolism==
    24 KB (3,339 words) - 16:46, 27 September 2010
  • Azithromycin
    | metabolism = [[Hepatic]] == Metabolism ==
    15 KB (2,008 words) - 16:46, 27 September 2010
  • Metformin
    | metabolism = None Metformin is not [[drug metabolism|metabolized]]. It is [[clearance (medicine)|cleared]] from the body by [[re
    66 KB (8,976 words) - 16:47, 27 September 2010
  • Valproic acid
    | metabolism = [[Liver|Hepatic]]—[[glucuronidation|glucuronide conjugation]] 30–50%, ...Graw-Hill]] |location=New York |isbn=978-0071422802|pages=79 |chapter=Drug Metabolism }}</ref> By inhibiting mEH, valproic acid causes a buildup of the active me
    25 KB (3,328 words) - 16:47, 27 September 2010
  • Fluoxetine
    | metabolism = Hepatic ...fluoxetine_cp.htm | title = Prozac Pharmacology, Pharmacokinetics,Studies, Metabolism | year = 2007 | accessdate = 2007-04-14 | publisher = RxList.com}}</ref>
    52 KB (7,168 words) - 16:47, 27 September 2010
  • Promethazine
    | bioavailability = 88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability | metabolism = [[Liver|Hepatic]] [[glucuronidation]] and [[sulfoxide|sulfoxidation]]
    10 KB (1,347 words) - 21:10, 12 September 2010
  • Activated carbon
    ...s control systems as the gas is undetectable to the human senses, toxic to metabolism and neurotoxic.
    41 KB (5,738 words) - 16:47, 27 September 2010
  • Aspirin
    | metabolism = [[Liver|Hepatic]] As much as 80% of therapeutic doses of salicylic acid is [[metabolism|metabolized]] in the [[liver]]. Conjugation with [[glycine]] forms [[salicy
    78 KB (10,918 words) - 16:52, 27 September 2010
  • Prussian blue
    | Metabolism =
    20 KB (3,004 words) - 16:47, 27 September 2010
  • Suramin
    | metabolism =
    7 KB (906 words) - 16:47, 27 September 2010
  • Triclabendazole
    | metabolism = oxidation to the sulfone and sulfoxide parent compound
    2 KB (288 words) - 14:52, 14 July 2010
  • Ampicillin
    | metabolism = 12 to 50%
    7 KB (881 words) - 16:47, 27 September 2010
  • Cefazolin
    | metabolism = ?
    4 KB (492 words) - 15:08, 6 July 2010
  • Cefixime
    | metabolism =
    2 KB (330 words) - 16:52, 27 September 2010
  • Cloxacillin
    | metabolism =
    3 KB (349 words) - 11:25, 20 September 2010
  • Phenoxymethylpenicillin
    | metabolism = [[hepatic]]
    5 KB (612 words) - 15:08, 6 July 2010
  • Omeprazole
    | metabolism = [[Liver|Hepatic]] ([[CYP2C19]], [[CYP3A4]]) ...nteraction|interact]] with drugs that depend on them for [[drug metabolism|metabolism]], such as [[diazepam]], [[escitalopram]], and [[warfarin]]; the concentrat
    17 KB (2,299 words) - 09:15, 5 September 2010
  • Amlodipine
    | metabolism = [[Liver|Hepatic]] ===Drug metabolism and excretion===
    12 KB (1,641 words) - 15:32, 16 September 2010
  • Atenolol
    | metabolism = [[Liver|Hepatic]] <10%
    12 KB (1,720 words) - 16:48, 27 September 2010
  • Enalapril
    | metabolism = hepatic (to enalaprilat)
    5 KB (725 words) - 16:48, 27 September 2010
  • Hydralazine
    | metabolism = Hepatic
    5 KB (641 words) - 16:48, 27 September 2010
  • Hydrochlorothiazide
    ...urnal |author=Beermann B, Groschinsky-Grind M, Rosén A.|title=Absorption, metabolism, and excretion of hydrochlorothiazide |journal=Clin Pharmacol Ther |volume=
    5 KB (655 words) - 16:48, 27 September 2010
  • Methyldopa
    | metabolism = [[Liver|Hepatic]]
    8 KB (905 words) - 10:56, 20 September 2010
  • Sodium nitroprusside
    | Metabolism = Circulatory ==Metabolism and toxicity==
    9 KB (1,095 words) - 16:48, 27 September 2010
  • Digoxin
    | metabolism = [[Liver|Hepatic]] (16%)
    19 KB (2,738 words) - 16:48, 27 September 2010

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