Haloxazolam

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Haloxazolam
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Systematic (IUPAC) name
13-bromo- 2-(2-fluorophenyl)- 3-oxa- 6,9-diazatricyclo [8.4.0.02,6] tetradeca- 1(10),11,13- trien- 8-one
Clinical data
Pregnancy
category
  •  ?
Routes of
administration		 Oral
Legal status
Legal status
Pharmacokinetic data
Bioavailability ?
Metabolism Hepatic
Biological half-life ?
Excretion Renal
Identifiers
CAS Number 59128-97-1
ATC code none
PubChem CID 3563
Chemical data
Formula C17H14BrFN2O2
Molar mass 377.208 g/mol[[Script error: No such module "String".]]
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Haloxazolam (marketed in Japan under the brand name Somelin), is a drug which is a benzodiazepine derivative.[1][2][3] It has similar hypnotic properties as the benzodiazepine drugs triazolam and flunitrazepam.[4] A study in cats comparing estazolam and haloxazolam found that haloxazolam only effects gamma motor neurons, whereas estazolam effects both alpha and gamma motor neurons.[5]

See also

References

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Benzodiazepine derivatives (N05BA, N05CD)
1,4-Benzodiazepines

Bromazepam · Camazepam · Carburazepam · Chlordiazepoxide · Cinolazepam · Clonazepam · Clorazepate · Cyprazepam · Delorazepam · Demoxepam · Devazepide* · Diazepam · Doxefazepam · Elfazepam · Ethyl carfluzepate · Ethyl dirazepate · Ethyl loflazepate · Fletazepam · Fludiazepam · Flunitrazepam · Flurazepam · Flutemazepam · Flutoprazepam · Fosazepam · Gidazepam · Halazepam · Iclazepam · Ketazolam · Lorazepam · Lormetazepam · Meclonazepam · Medazepam · Menitrazepam · Metaclazepam · Motrazepam · Nimetazepam · Nitrazepam · Nitrazepate · Nordazepam · Nortetrazepam · Oxazepam · Phenazepam · Pinazepam · Pivoxazepam · Prazepam · Proflazepam · Quazepam · QH-II-66 · Reclazepam · Ro5-2904 · Sulazepam · Temazepam · Tetrazepam · Tifluadom* · Tolufazepam · Tuclazepam · Uldazepam

1,5-Benzodiazepines
2,3-Benzodiazepines *
Triazolobenzodiazepines
Imidazobenzodiazepines
Oxazolobenzodiazepines

Cloxazolam · Flutazolam · Haloxazolam · Mexazolam · Oxazolam

Thienodiazepines
Pyridodiazepines
Pyrazolodiazepines
Pyrrolodiazepines
Tetrahydroisoquinobenzodiazepines
Benzodiazepine prodrugs
 * atypical activity profile (not GABAA receptor ligands)


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sv:Haloxazolam ja:ハロキサゾラム
  1. ↑ Tanaka, E; Terada, M; Misawa, S; Wakasugi, C (1996). "Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel". Journal of chromatography. B, Biomedical applications. 682 (1): 173–8. doi:10.1016/0378-4347(96)00121-1. PMID 8832439. 
  2. ↑ "Benzodiazepine Names". non-benzodiazepines.org.uk. Retrieved 2009-04-05. 
  3. ↑ Guan, F; Seno, H; Ishii, A; Watanabe, K; Kumazawa, T; Hattori, H; Suzuki, O (1999). "Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of analytical toxicology. 23 (1): 54–61. PMID 10022210. 
  4. ↑ Tan, X; Uchida, S; Matsuura, M; Nishihara, K; Kojima, T (2003). "Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra". Psychiatry and clinical neurosciences. 57 (1): 97–104. doi:10.1046/j.1440-1819.2003.01085.x. PMID 12519461. 
  5. ↑ Sakai, Y (1983). "Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems". Japanese journal of pharmacology. 33 (5): 1017–25. doi:10.1254/jjp.33.1017. PMID 6139494. 
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