Adinazolam

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Adinazolam
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Systematic (IUPAC) name
1-(8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,5-a]
[1,4]benzodiazepin-1-yl)-N,N-dimethylmethanamine
Clinical data
Pregnancy
category
  •  ?
Routes of
administration
Oral
Legal status
Legal status
  • Schedule IV(US)
Pharmacokinetic data
Bioavailability ?
Metabolism Hepatic
Biological half-life < 3 hours
Excretion Renal
Identifiers
CAS Number 37115-32-5
ATC code N05BA07 (WHO)
PubChem CID 37632
DrugBank APRD00724
ChemSpider 34519
Chemical data
Formula C19H18ClN5
Molar mass 351.8[[Script error: No such module "String".]]
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Adinazolam (marketed under the brand name Deracyn) is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative, and antidepressant[1] properties. Adinazolam was developed by Dr. Jackson B. Hester, who was seeking to enhance the antidepressant properties of alprazolam, which he also developed.[2]

Indications

Adinazolam is indicated as a treatment for anxiety and status epilepticus.

Pharmacology

Adinazolam produces inhibitory effects by binding to GABA receptors. This increases the effects of GABA.

Metabolism

Adinazolam was reported to have active metabolites in the August 1984 issue of The Journal of Pharmacy and Pharmacology.[3] The main metabolite is N-desmethyladinazolam.[4] The other two metabolites are alpha-hydroxyalprazolam and estazolam.[5] In the August 1986 issue of that same journal, Sethy, Francis and Day reported that proadifen inhibited the formation of N-desmethyladinazolam.[6]

Chemistry

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Hester, J. B.; Rudzik, A. D.; Von Voigtlander, P. F.; J. Med. Chem. 1980, 23, 392.

http://dx.doi.org/10.1021/jm00178a009

See also

References

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