|Systematic (IUPAC) name|
7-bromo- 5-(2-chlorophenyl)- 1,3-dihydro- 2H- 1,4-benzodiazepin- 2-one
|Biological half-life||60 hours|
|Molar mass||349.609[[Script error: No such module "String".]]|
Phenazepam is a benzodiazepine drug, which was developed in the Soviet Union and now produced in Russia and some CIS countries. Phenazepam is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal syndrome and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety.
An average phenazepam dosage is 0.5 mg 2-3 times daily. The maximum daily dosage must not exceed 10 mg.
Side effects include dizziness, loss of coordination and drowsiness, along with anterograde amnesia which can be quite pronounced at high doses. As with other benzodiazepines, in case of abrupt discontinuation following prolonged use, severe withdrawal symptoms may occur including restlessness, anxiety, insomnia and convulsions.
Contraindications and special caution
Phenazepam does not appear in the list of Controlled Substances in the Laws of either the USA or the UK, where in each country, benzodiazepines are generally Class C, Schedule IV substances.
In the United States the Controlled Substance Analogue Act applies only to substances in Schedule I and Schedule II. To this date there are no benzodiazepines in either of these schedules, and as such, all benzodiazepines not explicitly scheduled fall outside the analogue act.
Phenazepam is now considered a narcotic in Norway as the health department put the drug on the regular narcotic list as of March 24. 2010
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- Species differences in phenazepam kinetics and metabolism, National Center for Biotechnology Information, USA
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