Lofendazam
From Self-sufficiency
| 150px | |
| Systematic (IUPAC) name | |
|---|---|
|
8-chloro- 1-phenyl- 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-one | |
| Identifiers | |
| CAS Number | 29176-29-2 |
| ATC code | none |
| PubChem | CID 71709 |
| Chemical data | |
| Formula | C15H13ClN2O |
| Molar mass | 272.73[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
Lofendazam is an organic molecule which is a benzodiazepine derivative. Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam. [1][2]
Lofendazam as a human pharmaceutical has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam.[3]
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See also
References
- ↑ Malik F, Hasan M, Khan KM, Perveen S, Snatzke G, Duddeck H, Voelter W. Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-ones. Liebigs Annalen der Chemie, 1995. (10):1861-1869.
- ↑ Aversa MC, Giannetto P, Romeo G, Ficarra P, Vigorita MG. Nuclear magnetic resonance spectra of psychotherapeutic agents. V* - conformational analysis of 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-ones. Organic Magnetic Resonance, 1981. 15(4):394-398
- ↑ J. Adrien, F. Albani, A. Baruzzi, M. Berger, E.O. Bixler, A.A. Borbeley, D.G. Dikeos, R. Drucker-Colin, R. Fritsch Montero, Y. Hishikawa, S. Inoue, A. Kales, E. Lugaresi, H. Merchant-Nancy, J.M. Monti. The Pharmacology of Sleep. Springer. ISBN 978-3540589617
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