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Systematic (IUPAC) name
Clinical data
Routes of
Legal status
Legal status
Pharmacokinetic data
Bioavailability 100%
Protein binding 92%
Metabolism Hepatic
Biological half-life 90–111 minutes
CAS Number 71195-58-9
ATC code N01AH02 (WHO)
PubChem CID 51263
DrugBank APRD00726
ChemSpider 46451
Chemical data
Formula C21H32N6O3
Molar mass 416.517 g/mol[[Script error: No such module "String".]]
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Physical data
Melting point 140.8 °C (285.4 °F)
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Alfentanil (trade name Alfenta, Rapifen in Australia) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with around 1/10 the potency of fentanyl and around 1/3 of the duration of action, but with an onset of effects 4x faster than fentanyl.[1] It is an OP3 mu-agonist.

While alfentanil tends to cause less cardiovascular complications than other similar drugs such as fentanyl and remifentanil it tends to give stronger respiratory depression and so requires careful monitoring of breathing and vital signs. Alfentanil is administered by the parenteral (injected) route for fast onset of effects and precise control of dosage.

Alfentanil is a restricted drug which is classified as Schedule II in the USA, according to the U.S. DEA website.[2]

Alfentanil was discovered at Janssen Pharmaceutica in 1976.


External links


es:Alfentanilo fa:آلفنتانیل fr:Alfentanil pl:Alfentanyl pt:Alfentanil sv:Alfentanil th:อัลเฟนทานิล