Xylazine

Xylazine

File:Xylazin.svg
Systematic (IUPAC) name
N-​(2,6-​dimethylphenyl)-​5,6-​dihydro-​4H-​1,3-​thiazin-​2-​amine
Legal status
Legal status	Veterinary Use
Identifiers
CAS Number	7361-61-7
ATCvet code	QN05CM92 (WHO)
PubChem	CID 5707
IUPHAR/BPS	523
Chemical data
Formula	C12H16N2S
Molar mass	220.33[[]]
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Xylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist at the α₂ class of adrenergic receptor. As with other α₂ agonists, adverse effects include bradycardia, conduction disturbances, and myocardial depression. Yohimbine (Yobine) and atipamezole (commercial name Antisedan) can be used to reverse xylazine effects. In veterinary anesthesia, xylazine is often used in combination with ketamine. No formal information in humans is available. Xylazine is sold by Bayer under the brand name Rompun.

Veterinary Indications

Veterinarians use xylazine as an emetic when it is desirable to remove a substance from a cat's stomach. In one trial, pilocarpine was used instead of xylazine.

References

• McCurnin, DM, and JM Bassert. Clinical Textbook for Veterinary Technicians, 5th ed. Saunders, Philadelphia, PA. 2002.
• Bayer Healthcare - Rompun Homepage http://www.rompun.com/. 2005.
• Wright, Dr. Bob. Human Health Concerns When Working With Medications Around Horses. Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA). http://www.omafra.gov.on.ca/english/livestock/horses/facts/00-063.html. 2005.

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