Difference between revisions of "Tiaprofenic acid"

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Tiaprofenic acid
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Systematic (IUPAC) name
(RS)-2-(5-benzoyl-2-thienyl)propanoic acid
Clinical data
Pregnancy
category
  • C
Routes of
administration		 oral
Legal status
Legal status
  • POM
Pharmacokinetic data
Bioavailability 90%
Metabolism 10% hepatic
Biological half-life 1.5-2.5h
Excretion 50-80% urine
Identifiers
CAS Number 33005-95-7
ATC code M01AE11 (WHO)
PubChem CID 5468
Synonyms 5-Benzoyl-α-methyl-2-thiopheneacetic acid
Chemical data
Formula C14H12O3S
Molar mass 260.309[[Script error: No such module "String".]]
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Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300mg twice daily. It is not recommended in children.

It is sparingly metabolised in the liver to two inactive metabolites. Most of the drug is eliminated unchanged in the urine. Renal disease impairs excretion, and it should be used with caution in renal disease.

Longterm use of tiaprofenic acid is associated with severe cystitis, roughly 100 times more commonly than other NSAIDs. It is contraindicated in patients with cystitis and urinary tract infections.

It is marketed under the trade names Surgam, Surgamyl and Tiaprofen, and in generic formulations. A sustained-release preparation is available.

References

  • Crawford MLA, Waller PC, Wood SM. Severe cystitis associated with tiaprofenic acid. British Journal of Urology 1997; 79(4): 578-584.

External links

  • Manufacturer Data Sheet [1]
Non-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)
Salicylates
Arylalkanoic acids
2-Arylpropionic acids
(profens)
N-Arylanthranilic acids
(fenamic acids)
Pyrazolidine derivatives
Oxicams
COX-2 inhibitors
Sulfonanilides
Topically used products
COX-inhibiting nitric oxide donators
Others
Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.
Pyrazolidine/Butylpyrazolidines
Acetic acid derivatives
and related substances
Oxicams
Propionic acid derivatives
Fenamates
Coxibs
Other

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)


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