Difference between revisions of "Indoprofen"

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Indoprofen
File:Indoprofen.svg
Systematic (IUPAC) name
2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)
phenyl]propanoic acid
Clinical data
Routes of
administration		 Oral
Legal status
Legal status
  • Withdrawn
Pharmacokinetic data
Bioavailability High (rapid and complete absorption)
Metabolism Glucuronidation
Biological half-life 2.3 hours
Excretion Renal
Identifiers
CAS Number 31842-01-0
ATC code M01AE10 (WHO)
PubChem CID 3718
Chemical data
Formula C17H15NO3
Molar mass 281.306 g/mol[[Script error: No such module "String".]]
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Indoprofen is a non-steroidal anti-inflammatory drug. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.[1]

A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.[1][2]

References

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Pyrazolidine/Butylpyrazolidines
Acetic acid derivatives
and related substances
Oxicams
Propionic acid derivatives
Fenamates
Coxibs
Other

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

Non-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)
Salicylates
Arylalkanoic acids
2-Arylpropionic acids
(profens)
N-Arylanthranilic acids
(fenamic acids)
Pyrazolidine derivatives
Oxicams
COX-2 inhibitors
Sulfonanilides
Topically used products
COX-inhibiting nitric oxide donators
Others
Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.


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bs:Indoprofen sv:Indoprofen
  1. ↑ 1.0 1.1 Frazin, Natalie (March 9, 2005). "Pain Reliever May Provide Clues for Treating Spinal Muscular Atrophy". United States National Institute of Neurological Disorders and Stroke. Retrieved 2007-10-06. 
  2. ↑ Lunn MR, Root DE, Martino AM; et al. (2004). "Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism". Chem Biol. 11 (11): 1489–93. doi:10.1016/j.chembiol.2004.08.024. PMID 15555999. 
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