Tiaprofenic acid
| 250px | |
| Systematic (IUPAC) name | |
|---|---|
|
(RS)-2-(5-benzoyl-2-thienyl)propanoic acid | |
| Clinical data | |
| Pregnancy category |
|
| Routes of administration | oral |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | 90% |
| Metabolism | 10% hepatic |
| Biological half-life | 1.5-2.5h |
| Excretion | 50-80% urine |
| Identifiers | |
| CAS Number | 33005-95-7 |
| ATC code | M01AE11 (WHO) |
| PubChem | CID 5468 |
| Synonyms | 5-Benzoyl-α-methyl-2-thiopheneacetic acid |
| Chemical data | |
| Formula | C14H12O3S |
| Molar mass | 260.309[[Script error: No such module "String".]] |
| (verify) | |
Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300mg twice daily. It is not recommended in children.
It is sparingly metabolised in the liver to two inactive metabolites. Most of the drug is eliminated unchanged in the urine. Renal disease impairs excretion, and it should be used with caution in renal disease.
Longterm use of tiaprofenic acid is associated with severe cystitis, roughly 100 times more commonly than other NSAIDs. It is contraindicated in patients with cystitis and urinary tract infections.
It is marketed under the trade names Surgam, Surgamyl and Tiaprofen, and in generic formulations. A sustained-release preparation is available.
References
- Crawford MLA, Waller PC, Wood SM. Severe cystitis associated with tiaprofenic acid. British Journal of Urology 1997; 79(4): 578-584.
External links
- Manufacturer Data Sheet [1]
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