Zolazepam

Zolazepam

160px
160px
Systematic (IUPAC) name
4-​(2-​fluorophenyl)-​1,3,8-​trimethyl-​6,8-​dihydropyrazolo[3,4-e]​[1,4]diazepin-​7(1H)-​one
Identifiers
CAS Number	31352-82-6
ATC code	none
PubChem	CID 35775
Chemical data
Formula	C15H15FN4O
Molar mass	286.304[[]]

Zolazepam (Flupyrazapon) is a pyrazolodiazepinone derivative structurally related to the benzodiazepine drugs, which is used as an anaesthetic for a wide range of animals in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA antagonist tiletamine or the alpha-2 adrenergic receptor agonist xylazine, depending on what purpose it is being used for.

Zolazepam was developed by Horace A. de Wald and Donald E. Butler for Parke Davis and was the result of a very detailed analysis of the benzodiazepine structure (US Patent 3,558,605 filed in 1969).

Zolazepam, in combination with tiletamine, has been used in the tranquilization of wild animals, such as gorillas and polar bears, and has been found to be in terms of reduced side-effects superior to ketamine.

500px

Dewald, Horace A.; Lobbestael, Sandra; Butler, Donald E. (1977). "Pyrazolodiazepines. 2. 4-Aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e][1,4]diazepin-7(1H)-ones as antianxiety and anticonvulsant agents". Journal of Medicinal Chemistry. 20 (12): 1562. doi:10.1021/jm00222a005. PMID 22748. 

See also

• Benzodiazepine