Fostedil

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Fostedil
File:Fostedil structure.png
Systematic (IUPAC) name
diethyl [4-(1,3-benzothiazol-2-yl)benzyl]phosphonate
Clinical data
Routes of
administration		 Oral
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number 75889-62-2
ATC code none
PubChem CID 53421
ChemSpider 48253
Chemical data
Formula C18NO3PS
Molar mass 361.40 g/mol[[Script error: No such module "String".]]
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Fostedil (A-53,986, KB-944) is a vasodilator acting as a calcium channel blocker which was under development for the treatment of heart conditions such as angina pectoris but was never marketed.[1][2][3][4] It has antihypertensive and antiarrhythmic effects.[5][6][7]

Synthesis

450px[8]

See also

References

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Medications used in the management of pulmonary arterial hypertension (B01, C02)
Prostacyclin analogues
Endothelin receptor antagonists
PDE5 inhibitors
Adjunctive therapy
Channel blockers
class Ia (Phase 0→ and Phase 3→)
class Ib (Phase 3←)
class Ic (Phase 0→)
Receptor agonists
and antagonists
Propranolol • Nadolol • Pindolol • cardioselective (Atenolol, Metoprolol, Acebutolol, Esmolol)
Ion transporters
Selective
Dihydropyridines ("-dipine")
1-4 Benzothiazepines ("-tiazem")
Non-selective
Other/ungrouped
Amrinone  • Anandamide  • Anipamil  • Azimilide  • Bencyclane  • Bepridil  • Berbamine  • Bevantolol  • Canadine  • Carboxyamidotriazole  • Caroverine  • Cinnarizine  • Conotoxins  • Darodipine  • Dauricine  • Devapamil  • Dimeditiapramine  • Dotarizine  • Emopamil  • Enpiperate  • Eperisone  • Falipamil  • Fantofarone  • Fasudil  • Fenamic acid  • Fendiline  • Flunarizine  • Fostedil  • Gabapentin  • Lamotrigine  • Lidoflazine  • Magnesium sulfate  • Manoalide  • Mepirodipine  • Mibefradil‡  • Monatepil  • Naftopidil  • Niguldipine  • Niludipin  • Norverapamil  • Ochratoxin A  • Octylonium  • Osthol  • Oxodipine  • Perhexiline  • Pinaverium  • Piperidine  • Pregabalin  • Prenylamine  • Risedronic acid  • Ryodipine  • Sesamodil  • Stepholidine  • Terodiline  • Tetrahydropalmatine  • Tetrandrine  • Tolfenamic acid  • Tranilast
  1. ↑ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. 
  2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. ↑ Morita T, Yoshino K, Kanazawa T, Ito K, Nose T (1982). "Vasodilator action of KB-944, a new calcium antagonist". Arzneimittel-Forschung. 32 (9): 1037–42. PMID 6890822. 
  4. ↑ Morita T, Kanazawa T, Ito K, Nose T (1982). "Vasodilator mechanism of KB-944, a new calcium antagonist". Arzneimittel-Forschung. 32 (9): 1043–6. PMID 6890823. 
  5. ↑ Morita T, Kanazawa T, Ito K, Nose T (1982). "Antihypertensive effect of KB-944, a new calcium antagonist, in conscious normotensive and hypertensive rats". Arzneimittel-Forschung. 32 (9): 1047–52. PMID 6890824. 
  6. ↑ Morita T, Ito K, Nose T (1982). "Cardiac action of KB-944, a new calcium antagonist". Arzneimittel-Forschung. 32 (9): 1053–5. PMID 6890825. 
  7. ↑ Yoshidomi M, Sukamoto T, Morita T, Ito K, Nose T (1982). "Antiarrhythmic effect of KB-944, a new calcium antagonist. A comparison with verapamil and diltiazem". Arzneimittel-Forschung. 32 (9): 1056–9. PMID 6890826. 
  8. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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