OR1D2

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Olfactory receptor, family 1, subfamily D, member 2
Identifiers
Symbols	OR1D2; MGC119942; MGC119943; OLFR1; OR17-4
External IDs	OMIM: 164342 MGI: 3030246 HomoloGene: 37634 GeneCards: OR1D2 Gene
Gene Ontology Molecular function • receptor activity • olfactory receptor activity Cellular component • integral to plasma membrane • membrane Biological process • cell motility • signal transduction • G-protein coupled receptor protein signaling pathway • sensory perception of smell • response to stimulus Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4991	258153
Ensembl	ENSG00000184166	ENSMUSG00000058275
UniProt	P34982	n/a
RefSeq (mRNA)	NM_002548	NM_001011851
RefSeq (protein)	NP_002539	NP_001011851
Location (UCSC)	Chr 17: 2.94 - 2.94 Mb	Chr 11: 74.18 - 74.18 Mb
PubMed search	[1]	[2]

Olfactory receptor 1D2 is a protein that in humans is encoded by the OR1D2 gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Selbie LA, Townsend-Nicholson A, Iismaa TP, Shine J (1992). "Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences". Brain Res. Mol. Brain Res. 13 (1-2): 159–63. doi:10.1016/0169-328X(92)90057-I. PMID 1315913. CS1 maint: Multiple names: authors list (link)
• Ben-Arie N, Lancet D, Taylor C; et al. (1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum. Mol. Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schurmans S, Muscatelli F, Miot F; et al. (1993). "The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13→p12 region of the human genome and reveals an MspI restriction fragment length polymorphism". Cytogenet. Cell Genet. 63 (3): 200–4. doi:10.1159/000133534. PMID 8097991. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nekrasova E, Sosinskaya A, Natochin M; et al. (1996). "Overexpression, solubilization and purification of rat and human olfactory receptors". Eur. J. Biochem. 238 (1): 28–37. doi:10.1111/j.1432-1033.1996.0028q.x. PMID 8665947. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Glusman G, Sosinsky A, Ben-Asher E; et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fuchs T, Malecova B, Linhart C; et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Spehr M, Gisselmann G, Poplawski A; et al. (2003). "Identification of a testicular odorant receptor mediating human sperm chemotaxis". Science. 299 (5615): 2054–8. doi:10.1126/science.1080376. PMID 12663925. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993 Freely accessible. PMID 14983052. CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• MeSH OR1D2+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.