THIQ

From Self-sufficiency
Jump to: navigation, search
THIQ
File:THIQ structure.png
Systematic (IUPAC) name
N-[(3R)-1,2,3,4-tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl) -2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1ylmethyl)piperidin-1-yl]-2-oxoethylamine
Identifiers
CAS Number 312637-48-2
PubChem CID 9938402
Chemical data
Formula C33H41ClN6O2
Molar mass 589.169[[Script error: No such module "String".]]
Script error: No such module "collapsible list".
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

THIQ is a drug used in scientific research, which is the first non-peptide agonist developed that is selective for the melanocortin receptor subtype MC4.[1][2] In animal studies, THIQ stimulated sexual activity in rats,[3] but with little effect on appetite or inflammation.[4] This supports possible application of MC4 selective agonists for the treatment of sexual dysfunction in humans,[5] although THIQ itself has poor oral bioavailability and a short duration of action so improved analogues will need to be developed.[6]

See also

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />


  1. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  4. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  5. Jump up Shadiack AM, Sharma SD, Earle DC, Spana C, Hallam TJ (2007). "Melanocortins in the treatment of male and female sexual dysfunction". Current Topics in Medicinal Chemistry. 7 (11): 1137–44. doi:10.2174/156802607780906681. PMID 17584134. 
  6. Jump up King SH, Mayorov AV, Balse-Srinivasan P, Hruby VJ, Vanderah TW, Wessells H (2007). "Melanocortin receptors, melanotropic peptides and penile erection". Current Topics in Medicinal Chemistry. 7 (11): 1098–1106. PMC 2694735Freely accessible. PMID 17584130.