Neurotensin receptor

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neurotensin receptor 1 (high affinity)
Identifiers
Symbol NTSR1
Alt. symbols NTR
Entrez 4923
HUGO 8039
OMIM 162651
RefSeq NM_002531
UniProt P30989
Other data
Locus Chr. 20 q13-20q13
neurotensin receptor 2
Identifiers
Symbol NTSR2
Alt. symbols NTR2
Entrez 23620
HUGO 8040
OMIM 605538
RefSeq NM_012344
UniProt O95665
Other data
Locus Chr. 2 p25.1
sortilin 1
Identifiers
Symbol SORT1
Alt. symbols Gp95, NT3
Entrez 6272
HUGO 11186
OMIM 602458
RefSeq NM_002959
UniProt Q99523
Other data
Locus Chr. 1 p21.3-1p13.1

The neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin.[1][2] Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled. The third receptor has a single transmembrane domain and is encoded by the SORT1 gene.

Ligands

Agonists

Peptide
  • Beta-lactotensin (NTS2 selective)[3]
  • JMV-449
  • Neurotensin
  • Neuromedin N (NTS1 selective)
  • PD-149,163 (NTS1 selective, reduced amide bond 8-13 fragment of neurotensin)
Non-peptide
  • Partial agonists derived from SR-48692[4]

Antagonists

References

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External links


  1. Vincent JP, Mazella J, Kitabgi P (1999). "Neurotensin and neurotensin receptors". Trends Pharmacol. Sci. 20 (7): 302–9. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649. 
  2. Pelaprat D (2006). "Interactions between neurotensin receptors and G proteins". Peptides. 27 (10): 2476–87. doi:10.1016/j.peptides.2006.04.027. PMID 16919370. 
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