Galanin receptor 1

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Galanin receptor 1
Identifiers
SymbolsGALR1; GALNR; GALNR1
External IDsOMIM600377 MGI1096364 HomoloGene74396 IUPHAR: GAL1 GeneCards: GALR1 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez258714427
EnsemblENSG00000166573ENSMUSG00000024553
UniProtP47211P56479
RefSeq (mRNA)NM_001480NM_008082
RefSeq (protein)NP_001471NP_032108
Location (UCSC)Chr 18:
73.09 - 73.11 Mb
Chr 18:
82.53 - 82.54 Mb
PubMed search[1][2]

Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene.[1]

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.[1]

See also

References

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External links

  • "Galanin Receptors: GAL1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  1. 1.0 1.1 "Entrez Gene: GALR1 galanin receptor 1".