GR-159,897

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GR-159,897
File:GR-159,897 chemical structure.png
Systematic (IUPAC) name
5-fluoro-3-(2-(4-methoxy-4-([(R)-phenylsulphinyl]methyl)-1-piperidinyl)ethyl)-1H-indole
Identifiers
CAS Number 158848-32-9
PubChem CID 9555764
Chemical data
Formula C23H27FN2O2S
Molar mass 414.535 g/mol[[Script error: No such module "String".]]
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GR-159,897 is a potent and selective NK2 receptor antagonist drug.[1] It has anxiolytic effects in animal models,[2] and also inhibits bronchoconstriction of the airways, which may potentially make it useful in the treatment of asthma.[3][4]

See also

References

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GABAA PAMs
Others
α2δ VDCC Blockers
5-HT1A Agonists
Azapirones: Buspirone • Gepirone • Tandospirone; Others: Flesinoxan • Oxaflozane
H1 Antagonists
Diphenylmethanes: Captodiame • Hydroxyzine; Others: Brompheniramine • Chlorpheniramine • Pheniramine
CRH1 Antagonists
NK2 Antagonists
GR-159,897 • Saredutant
MCH1 antagonists
mGluR2/3 Agonists
mGluR5 NAMs
TSPO agonists
σ1 agonists
Others

M: PSO/PSI

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc, drug(N5A/5B/5C/6A/6B/6D)


35px This drug article relating to the nervous system is a stub. You can help ssf by expanding it.
  1. ↑ Beresford IJ, Sheldrick RL, Ball DI, Turpin MP, Walsh DM, Hawcock AB, Coleman RA, Hagan RM, Tyers MB. GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors. European Journal of Pharmacology. 1995 Jan 16;272(2-3):241-8. PMID 7713168
  2. ↑ Walsh DM, Stratton SC, Harvey FJ, Beresford IJ, Hagan RM. The anxiolytic-like activity of GR159897, a non-peptide NK2 receptor antagonist, in rodent and primate models of anxiety. Psychopharmacology (Berlin). 1995 Sep;121(2):186-91. PMID 8545524
  3. ↑ Advenier C. Tachykinin NK2 receptors further characterized in the lung with nonpeptide receptor antagonists. Canadian Journal of Physiology and Pharmacology. 1995 Jul;73(7):878-84. PMID 8846425
  4. ↑ Mizuta K, Gallos G, Zhu D, Mizuta F, Goubaeva F, Xu D, Panettieri RA Jr, Yang J, Emala CW Sr. Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2008 Mar;294(3):L523-34. PMID 18203813
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