Corticotropin releasing hormone receptor 1

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Corticotropin releasing hormone receptor 1
Identifiers
SymbolsCRHR1; CRF-R; CRF1; CRFR1; CRH-R1h; CRHR; CRHR1f
External IDsOMIM122561 MGI88498 HomoloGene20920 IUPHAR: CRF1 GeneCards: CRHR1 Gene
RNA expression pattern
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More reference expression data
Orthologs
SpeciesHumanMouse
Entrez139412921
EnsemblENSG00000120088ENSMUSG00000018634
UniProtP34998Q0VGH2
RefSeq (mRNA)XM_001128344NM_007762
RefSeq (protein)XP_001128344NP_031788
Location (UCSC)Chr 17:
41.24 - 41.27 Mb
Chr 11:
103.95 - 103.99 Mb
PubMed search[1][2]

Corticotropin releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF1, with the latter (CRF1) now being the IUPHAR-recommended name.[1] In humans, CRF1 is encoded by the CRHR1 gene.[2][3]

Function

The corticotropin-releasing hormone receptor binds to corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.[4]

CRF1 receptors in mice mediate ethanol enhancement of GABAergic synaptic transmission. [5]

Clinical significance

Variations in the CRHR1 gene is associated with enhanced response to inhaled corticosteroid therapy in asthma.[6] CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety.[7][8]

Interactions

Corticotropin releasing hormone receptor 1 has been shown to interact with Corticotropin-releasing hormone[9][10] and Urocortin.[11][10]

See also

References

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External links


Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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