Neurotensin receptor 2

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Neurotensin receptor 2
Identifiers
SymbolsNTSR2; NTR2
External IDsOMIM605538 MGI108018 HomoloGene7452 IUPHAR: NTS2 GeneCards: NTSR2 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2362018217
EnsemblENSG00000169006ENSMUSG00000020591
UniProtO95665Q8VIF4
RefSeq (mRNA)XM_001129997NM_008747
RefSeq (protein)XP_001129997NP_032773
Location (UCSC)Chr 2:
11.72 - 11.73 Mb
Chr 12:
16.68 - 16.69 Mb
PubMed search[1][2]

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[1][2][3]

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.[3]

See also

References

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External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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  3. 3.0 3.1 "Entrez Gene: NTSR2 neurotensin receptor 2".