OR3A4

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Olfactory receptor, family 3, subfamily A, member 4
Identifiers
Symbols	OR3A4; OR17-16; OR17-24; OLFRA05; OLFRA06; OR17-13; OR17-25; OR24; OR25; OR3A4P; OR3A5P
External IDs	MGI: 3030233 HomoloGene: 27325 GeneCards: OR3A4 Gene
Gene Ontology Molecular function • receptor activity • olfactory receptor activity Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • sensory perception of smell • response to stimulus Sources: Amigo / EGO
Orthologs
Species	Human	Mouse
Entrez	390756	259006
Ensembl	ENSG00000180068	ENSMUSG00000043692
UniProt	P47883	n/a
RefSeq (mRNA)	NM_001005334	NM_147004
RefSeq (protein)	NP_001005334	NP_667215
Location (UCSC)	Chr 17: 3.16 - 3.16 Mb	Chr 11: 73.87 - 73.87 Mb
PubMed search	[1]	[2]

Olfactory receptor 3A4 is a protein that in humans is encoded by the OR3A4 gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Ben-Arie N, Lancet D, Taylor C; et al. (1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum. Mol. Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Glusman G, Clifton S, Roe B, Lancet D (1997). "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity". Genomics. 37 (2): 147–60. doi:10.1006/geno.1996.0536. PMID 8921386. CS1 maint: Multiple names: authors list (link)
• Glusman G, Sosinsky A, Ben-Asher E; et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fuchs T, Malecova B, Linhart C; et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993 Freely accessible. PMID 14983052. CS1 maint: Multiple names: authors list (link)

External links

• MeSH OR3A4+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.