OR8B8

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Olfactory receptor, family 8, subfamily B, member 8
Identifiers
Symbols	OR8B8; TPCR85
External IDs	MGI: 2177528 HomoloGene: 56568 GeneCards: OR8B8 Gene
Gene Ontology Molecular function • receptor activity • olfactory receptor activity Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • sensory perception of smell • response to stimulus Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26493	258310
Ensembl	ENSG00000197125	ENSMUSG00000066748
UniProt	Q15620	Q60882
RefSeq (mRNA)	NM_012378	NM_146313
RefSeq (protein)	NP_036510	NP_666425
Location (UCSC)	Chr 11: 123.82 - 123.82 Mb	Chr 9: 37.65 - 37.65 Mb
PubMed search	[1]	[2]

Olfactory receptor 8B8 is a protein that in humans is encoded by the OR8B8 gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Gaudin JC, Breuils L, Haertlé T (2002). "New GPCRs from a human lingual cDNA library". Chem. Senses. 26 (9): 1157–66. doi:10.1093/chemse/26.9.1157. PMID 11705801. CS1 maint: Multiple names: authors list (link)
• Fuchs T, Malecova B, Linhart C; et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993 Freely accessible. PMID 14983052. CS1 maint: Multiple names: authors list (link)

External links

• MeSH OR8B8+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.