Alinidine

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Alinidine
File:Alinidine.png
Systematic (IUPAC) name
N-(2,6-dichlorophenyl)-N-(prop-2-en-1-yl)-4,5-dihydro-1H-imidazol-2-amine
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number 33178-86-8
ATC code none
PubChem CID 36354
ChemSpider 33429
Chemical data
Formula C12H13Cl2N3
Molar mass 270.16 g/mol[[Script error: No such module "String".]]
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Alinidine (ST567) is a negative chronotrope that was developed in the 70's and 80's. It causes bradycardia by inhibiting the pacemaker current by altering the maximal channel conductance and alter the voltage threshold.[1] The development of alinidine was halted because it was not sufficiently specific for its target. It also has a blocking effect on calcium channels and potassium channels. It also causes elongation of re-polarisation after an action potential.[2]

Alinidine did not improve outcomes among patients with acute myocardial infarction in a randomized controlled trial.[3]

References

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Sympatholytic (and closely related) antihypertensives (C02)
Sympatholytics
(antagonize α-adrenergic
vasoconstriction)
Central
Adrenergic release inhibitors
Peripheral
Indirect
Direct
Non-selective α blocker
Other antagonists
dual (Bosentan) • selective (Ambrisentan, Sitaxentan)
Selective
Dihydropyridines ("-dipine")
1-4 Benzothiazepines ("-tiazem")
Non-selective
Other/ungrouped
Amrinone  • Anandamide  • Anipamil  • Azimilide  • Bencyclane  • Bepridil  • Berbamine  • Bevantolol  • Canadine  • Carboxyamidotriazole  • Caroverine  • Cinnarizine  • Conotoxins  • Darodipine  • Dauricine  • Devapamil  • Dimeditiapramine  • Dotarizine  • Emopamil  • Enpiperate  • Eperisone  • Falipamil  • Fantofarone  • Fasudil  • Fenamic acid  • Fendiline  • Flunarizine  • Fostedil  • Gabapentin  • Lamotrigine  • Lidoflazine  • Magnesium sulfate  • Manoalide  • Mepirodipine  • Mibefradil‡  • Monatepil  • Naftopidil  • Niguldipine  • Niludipin  • Norverapamil  • Ochratoxin A  • Octylonium  • Osthol  • Oxodipine  • Perhexiline  • Pinaverium  • Piperidine  • Pregabalin  • Prenylamine  • Risedronic acid  • Ryodipine  • Sesamodil  • Stepholidine  • Terodiline  • Tetrahydropalmatine  • Tetrandrine  • Tolfenamic acid  • Tranilast
Antiarrhythmic III/delayed rectifier
Other/ungrouped/unknown
  1. ↑ Snyders DJ, Van Bogaert P-P: Alinidine modifies the pacemaker current in sheep Purkinje fibers. Pflugers Arch 1987, 410:83-91
  2. ↑ Current Opinion in Pharmacology 2007, 7:208–213
  3. ↑ Van de Werf F, Janssens L, Brzostek T, Mortelmans L, Wackers FJ, Willems GM; et al. (1993). "Short-term effects of early intravenous treatment with a beta-adrenergic blocking agent or a specific bradycardiac agent in patients with acute myocardial infarction receiving thrombolytic therapy". J Am Coll Cardiol. 22 (2): 407–16. PMID 8335810. 
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