Difference between revisions of "Alinidine"

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'''Alinidine''' ('''ST567''') is a negative [[chronotrope]] that was developed in the 70's and 80's. It causes [[bradycardia]] by inhibiting the pacemaker current by altering the maximal channel conductance and alter the voltage threshold.<ref>Snyders DJ, Van Bogaert P-P: Alinidine modifies the pacemaker current in sheep Purkinje fibers. Pflugers Arch 1987, 410:83-91</ref> The development of alinidine was halted because it was not sufficiently specific for its target. It also has a blocking effect on [[Calcium channel|calcium channels]] and [[Potassium channel|potassium channels]]. It also causes elongation of re-polarisation after an [[action potential]].<ref>Current Opinion in Pharmacology 2007, 7:208–213</ref>
 
'''Alinidine''' ('''ST567''') is a negative [[chronotrope]] that was developed in the 70's and 80's. It causes [[bradycardia]] by inhibiting the pacemaker current by altering the maximal channel conductance and alter the voltage threshold.<ref>Snyders DJ, Van Bogaert P-P: Alinidine modifies the pacemaker current in sheep Purkinje fibers. Pflugers Arch 1987, 410:83-91</ref> The development of alinidine was halted because it was not sufficiently specific for its target. It also has a blocking effect on [[Calcium channel|calcium channels]] and [[Potassium channel|potassium channels]]. It also causes elongation of re-polarisation after an [[action potential]].<ref>Current Opinion in Pharmacology 2007, 7:208–213</ref>
  
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Alinidine did not improve outcomes among patients with acute [[myocardial infarction]] in a [[randomized controlled trial]].<ref name="pmid8335810">{{cite journal| author=Van de Werf F, Janssens L, Brzostek T, Mortelmans L, Wackers FJ, Willems GM et al.| title=Short-term effects of early intravenous treatment with a beta-adrenergic blocking agent or a specific bradycardiac agent in patients with acute myocardial infarction receiving thrombolytic therapy. | journal=J Am Coll Cardiol | year= 1993 | volume= 22 | issue= 2 | pages= 407-16 | pmid=8335810  
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Alinidine did not improve outcomes among patients with acute [[myocardial infarction]] in a [[randomized controlled trial]].<ref name="pmid8335810">{{cite journal| author=Van de Werf F, Janssens L, Brzostek T, Mortelmans L, Wackers FJ, Willems GM et al.| title=Short-term effects of early intravenous treatment with a beta-adrenergic blocking agent or a specific bradycardiac agent in patients with acute myocardial infarction receiving thrombolytic therapy. | journal=J Am Coll Cardiol | year= 1993 | volume= 22 | issue= 2 | pages= 407–16 | pmid=8335810  
 
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=8335810 }}</ref>
 
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=8335810 }}</ref>
  

Revision as of 00:13, 20 September 2010

Alinidine
File:Alinidine.png
Systematic (IUPAC) name
N-(2,6-dichlorophenyl)-N-(prop-2-en-1-yl)-4,5-dihydro-1H-imidazol-2-amine
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number 33178-86-8
ATC code none
PubChem CID 36354
ChemSpider 33429
Chemical data
Formula C12H13Cl2N3
Molar mass 270.16 g/mol[[Script error: No such module "String".]]
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Alinidine (ST567) is a negative chronotrope that was developed in the 70's and 80's. It causes bradycardia by inhibiting the pacemaker current by altering the maximal channel conductance and alter the voltage threshold.[1] The development of alinidine was halted because it was not sufficiently specific for its target. It also has a blocking effect on calcium channels and potassium channels. It also causes elongation of re-polarisation after an action potential.[2]

Alinidine did not improve outcomes among patients with acute myocardial infarction in a randomized controlled trial.[3]

References

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Sympatholytic (and closely related) antihypertensives (C02)
Sympatholytics
(antagonize α-adrenergic
vasoconstriction)
Central
Adrenergic release inhibitors
Peripheral
Indirect
Direct
Non-selective α blocker
Other antagonists
dual (Bosentan) • selective (Ambrisentan, Sitaxentan)
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Antiarrhythmic III/delayed rectifier
Other/ungrouped/unknown
  1. ↑ Snyders DJ, Van Bogaert P-P: Alinidine modifies the pacemaker current in sheep Purkinje fibers. Pflugers Arch 1987, 410:83-91
  2. ↑ Current Opinion in Pharmacology 2007, 7:208–213
  3. ↑ Van de Werf F, Janssens L, Brzostek T, Mortelmans L, Wackers FJ, Willems GM; et al. (1993). "Short-term effects of early intravenous treatment with a beta-adrenergic blocking agent or a specific bradycardiac agent in patients with acute myocardial infarction receiving thrombolytic therapy". J Am Coll Cardiol. 22 (2): 407–16. PMID 8335810. 
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