Difference between revisions of "Flurbiprofen"

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Flurbiprofen
200px
Systematic (IUPAC) name
(RS)-2-(2-fluorobiphenyl-4-yl)propanoic acid
Clinical data
Pregnancy
category
Routes of
administration		 Oral
Legal status
Legal status
  • POM
Pharmacokinetic data
Protein binding > 99%
Metabolism Hepatic (CYP2C9)
Biological half-life 4.7-5.7 hours
Excretion Renal
Identifiers
CAS Number 5104-49-4
ATC code M01AE09 (WHO) , M02AA19, R02AX01, S01BC04
PubChem CID 3394
DrugBank APRD00753
Synonyms (±)-2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid
Chemical data
Formula C15H13FO2
Molar mass 244.261 g/mol[[Script error: No such module "String".]]
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Physical data
Melting point 117 °C (243 °F)
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Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis. [1] It is known by the following tradenames: Ansaid, marketed by Pfizer, Flurwood by W.Woodward and Froben, by Abbott. Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges (Strepsils Intensive).

A single enantiomer of racemate flurbiprofen, tarenflurbil [(R)-flurbiprofen)], is currently in clinical trials for the treatment of metastatic prostate cancer.

References

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Pyrazolidine/Butylpyrazolidines
Acetic acid derivatives
and related substances
Oxicams
Propionic acid derivatives
Fenamates
Coxibs
Other

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

Non-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)
Salicylates
Arylalkanoic acids
2-Arylpropionic acids
(profens)
N-Arylanthranilic acids
(fenamic acids)
Pyrazolidine derivatives
Oxicams
COX-2 inhibitors
Sulfonanilides
Topically used products
Bendazac · Diclofenac · Etofenamate · Felbinac · Flurbiprofen · Ibuprofen · Indometacin · Ketoprofen · Naproxen · Piroxicam · Suprofen
COX-inhibiting nitric oxide donators
Others
Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.
Topical products for joint and muscular pain (M02)
Anti-inflammatory preparations,
non-steroids
Acetic acid derivatives
Other
Benzydamine • Etofenamate • Piroxicam • Felbinac • Bufexamac • Ketoprofen • Bendazac • Naproxen • Ibuprofen • Feprazone • Niflumic acid • Meclofenamic acid • Flurbiprofen • Suxibuzone • Indometacin • Nifenazone
Capsaicin derivatives
Other
Opioids
See also: Opioids template
Opium & alkaloids thereof
Semi-synthetic opium
derivatives
Synthetic opioids
Pyrazolones
Cannabinoids
Anilides
Non-steroidal
anti-inflammatories
See also: NSAIDs template
Propionic acid class

Fenoprofen · Flurbiprofen · Ibuprofen · Ketoprofen · Naproxen · Oxaprozin

Oxicam class
Acetic acid class
Anthranilic acid
(fenamate) class
Atypical, Adjuvant & Potentiators,
Metabolic agents and miscellaneous
Throat preparations (R02)
Antiseptics
Antibiotics
Local anesthetics
Other
Flurbiprofen

M: RES

anat(n, x, l, c)/phys/devp

proc, drug(R1/2/3/5/6/7)


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  1. ↑ "Medical Dictionary, Houghton Mifflin Company". retrieved July 21, 2010.  Check date values in: |date= (help)
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