Aceclofenac

Aceclofenac

File:Aceclofenac.png
Systematic (IUPAC) name
2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid
Clinical data
Routes of administration	oral, topical
Legal status
Legal status	UK: POM (Prescription only)
Identifiers
CAS Number	89796-99-6
ATC code	M01AB16 (WHO) M02AA25
PubChem	CID 71771
Chemical data
Formula	C16H13Cl2NO4
Molar mass	354.18472 g/mol[[]]

Aceclofenac is a non-steroidal anti-inflammatory drug. It is manufactured by Intas Biopharmaceuticals, under the tradename Hifenac in various forms (tablets, gel, injection etc.). Kaptab Pharmaceuticals manufactures Aceclofenac in combination with Paracetamol under the trade name "Cincofen" (Aceclofenac 100 mg + Paracetamol 500 mg)

It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. The dose is 100 mg twice daily. It should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children.

Aceclofenac has higher anti-inflammatory action than conventional NSAIDS. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation.

References

• British National Formulary 55, March 2008; ISBN 978 085369 776 3 p. 537

• BRAND NAME:

AS RANGE AVAILABLE IN VARIOUS FORMS:

• PAINO (ACECLOFENAC 100 mg tablet, ESKAYEF BANGLADESH LIMITED)
• AS-100 (ACECLOFENAC 100 mg)
• AS PLUS (with PARACETAMOL 500 mg)
• AS SR (SUSTAINED RELEASED 200 mg)
• AS MR (with TIZANIDINE 2 mg)
• AS GEL (with OLIUM LINE,METHYL SALICATE, CAPSISUM)
• AS MYO (with THIOCOLCHICOSIDE 4 mg)
• AS 15 (with SERRATIOPEPTIDASE 15 mg)

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