Acemetacin
| File:Acemetacin.svg | |
| Systematic (IUPAC) name | |
|---|---|
|
2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| CAS Number | 53164-05-9 |
| ATC code | M01AB11 (WHO) |
| PubChem | CID 1981 |
| Chemical data | |
| Formula | C21H18ClNO6 |
| Molar mass | 415.82372 g/mol[[Script error: No such module "String".]] |
Acemetacin is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. It is manufactured by Merck under the tradename Emflex, and is available in the UK as a prescription-only drug. Other brand names for acemetacin include Rheutrop (Austria), Acemetadoc, Acephlogont, Azeat, Rantudil (Germany), Gamespir (Greece), Oldan, Reudol (Spain), Tilur (Switzerland).
Acemetacin, a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of acemetacin is that it reduces gastric damage when compared to indometacin.
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