Sarmazenil

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Sarmazenil
File:Sarmazenil.png
Systematic (IUPAC) name
Ethyl 7-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Identifiers
CAS Number 78771-13-8
ATCvet code QV03AB91 (WHO)
PubChem CID 71231
Chemical data
Formula C15H14ClN3O3
Molar mass 319.743 g/mol[[Script error: No such module "String".]]
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Sarmazenil (Ro15-3505) is a drug from the benzodiazepine family. It acts as a partial inverse agonist of benzodiazepine receptors,[1] meaning that it causes the opposite effects to most benzodiazepine drugs, and instead acts as an anxiogenic and convulsant. It is used in veterinary medicine to reverse the effects of benzodiazepine sedative drugs in order to rapidly re-awaken anaethetised animals.[2][3][4]

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See also

References

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Benzodiazepine derivatives (N05BA, N05CD)
1,4-Benzodiazepines

Bromazepam · Camazepam · Carburazepam · Chlordiazepoxide · Cinolazepam · Clonazepam · Clorazepate · Cyprazepam · Delorazepam · Demoxepam · Devazepide* · Diazepam · Doxefazepam · Elfazepam · Ethyl carfluzepate · Ethyl dirazepate · Ethyl loflazepate · Fletazepam · Fludiazepam · Flunitrazepam · Flurazepam · Flutemazepam · Flutoprazepam · Fosazepam · Gidazepam · Halazepam · Iclazepam · Ketazolam · Lorazepam · Lormetazepam · Meclonazepam · Medazepam · Menitrazepam · Metaclazepam · Motrazepam · Nimetazepam · Nitrazepam · Nitrazepate · Nordazepam · Nortetrazepam · Oxazepam · Phenazepam · Pinazepam · Pivoxazepam · Prazepam · Proflazepam · Quazepam · QH-II-66 · Reclazepam · Ro5-2904 · Sulazepam · Temazepam · Tetrazepam · Tifluadom* · Tolufazepam · Tuclazepam · Uldazepam

1,5-Benzodiazepines
2,3-Benzodiazepines *
Triazolobenzodiazepines
Imidazobenzodiazepines
Oxazolobenzodiazepines
Thienodiazepines
Pyridodiazepines
Pyrazolodiazepines
Pyrrolodiazepines
Tetrahydroisoquinobenzodiazepines
Benzodiazepine prodrugs
 * atypical activity profile (not GABAA receptor ligands)
  1. ↑ López-Romero B, Evrard G, Durant F, Sevrin M, George P. Molecular structure and stereoelectronic properties of sarmazenil--a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors): comparison with bretazenil and flumazenil. Bioorganic and Medicinal Chemistry. 1998 Oct;6(10):1745-57. PMID 9839004
  2. ↑ Henke J, Roberts U, Otto K, Lendl C, Matis U, Brill T, Erhardt W. Clinical investigations of an i.m. combination anesthesia with fentanyl/climazolam/xylazine and postoperative i.v. antagonism with naloxone/sarmazenil/yohimbine in guinea pigs. (German) Tierarztliche Praxis. 1996 Feb;24(1):85-7. PMID 8720962
  3. ↑ Janovsky M, Tataruch F, Ambuehl M, Giacometti M. A Zoletil-Rompun mixture as an alternative to the use of opioids for immobilization of feral red deer. Journal of Wildlife Diseases. 2000 Oct;36(4):663-9. PMID 11085427
  4. ↑ Walzer C, Huber C. Partial antagonism of tiletamine-zolazepam anesthesia in cheetah. Journal of Wildlife Diseases. 2002 Apr;38(2):468-72. PMID 12038151
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