CGS-9896

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CGS-9896
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Systematic (IUPAC) name
2-(4-chlorophenyl)-1H-pyrazolo[4,5-c]quinolin-3-one
Identifiers
CAS Number 77779-36-3
PubChem CID 108030
Chemical data
Formula C16H10ClN3O
Molar mass 295.7231 g/mol[[Script error: No such module "String".]]
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CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1]

CGS-9896 is a benzodiazepine receptor partial agonist, which produces long-lasting anxiolytic and anticonvulsant effects in animal studies, but does not produce sedative effects.[2][3] It also increases appetite,[4] and reduces the development of gastrointestinal ulcers following chronic stress.[5]

References

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  1. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. Jump up Bernasconi R, Marescaux C, Vergnes M; et al. (1988). "Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models". J Neural Transm. 71 (1): 11–27. doi:10.1007/BF01259406. PMID 3343593. 
  3. Jump up Rump S, Raszewski W, Gidynska T, Galecka E (1990). "Effects of CGS 9896 in acute experimental intoxication with fluostigmine". Arch Toxicol. 64 (5): 412–3. doi:10.1007/BF01973465. PMID 2206111. 
  4. Jump up Chen SW, Davies MF, Loew GH (1995). "Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake". Pharmacol Biochem Behav. 51 (2-3): 499–503. doi:10.1016/0091-3057(95)00020-W. PMID 7667375. 
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