Emapunil

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Emapunil
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Systematic (IUPAC) name
N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide
Identifiers
CAS Number 226954-04-7
ATC code none
PubChem CID 6433109
Chemical data
Formula C23H23N5O2
Molar mass 401.461 g/mol[[Script error: No such module "String".]]
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Emapunil (AC-5216, XBD-173) is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO.[1][2] This protein has multiple functions, among which is regulation of steroidogenesis,[3][4] particularly the production of neuroactive steroids such as allopregnanolone in the brain.[5][6][7] In both animal and human trials, emapunil produced fast acting anxiolytic and anti-panic effects, without producing sedation or withdrawal symptoms following cessation of use.[8][9] Emapunil is also used in its 11C radiolabelled form to map the distribution of TSPO receptors in the brain.[10][11]

References

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  2. Mealy NE, Bayés M, Lupone B, Balcells M. Update 2006: Psychiatric Disorders. Drugs of the Future. 2006;31(3): 259.
  3. Veenman L, Papadopoulos V, Gavish M (2007). "Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response". Current Pharmaceutical Design. 13 (23): 2385–405. doi:10.2174/138161207781368710. PMID 17692008. 
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