Emapunil
200px | |
Systematic (IUPAC) name | |
---|---|
N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide | |
Identifiers | |
CAS Number | 226954-04-7 |
ATC code | none |
PubChem | CID 6433109 |
Chemical data | |
Formula | C23H23N5O2 |
Molar mass | 401.461 g/mol[[Script error: No such module "String".]] |
Emapunil (AC-5216, XBD-173) is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO.[1][2] This protein has multiple functions, among which is regulation of steroidogenesis,[3][4] particularly the production of neuroactive steroids such as allopregnanolone in the brain.[5][6][7] In both animal and human trials, emapunil produced fast acting anxiolytic and anti-panic effects, without producing sedation or withdrawal symptoms following cessation of use.[8][9] Emapunil is also used in its 11C radiolabelled form to map the distribution of TSPO receptors in the brain.[10][11]
References
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- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Mealy NE, Bayés M, Lupone B, Balcells M. Update 2006: Psychiatric Disorders. Drugs of the Future. 2006;31(3): 259.
- ↑ Veenman L, Papadopoulos V, Gavish M (2007). "Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response". Current Pharmaceutical Design. 13 (23): 2385–405. doi:10.2174/138161207781368710. PMID 17692008.
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