NS-2664
From Self-sufficiency
| File:NS-2664.png | |
| Systematic (IUPAC) name | |
|---|---|
|
5-furan-3-yl-1-(3-imidazol-1-yl-phenyl)-1H-benzoimidazole | |
| Identifiers | |
| PubChem | CID 9840300 |
| Chemical data | |
| Formula | C20H14N4O |
| Molar mass | 326.351 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
NS-2664 (LS-193,048) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company Neurosearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2664 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has potent anticonvulsant effects in animal studies, but a relatively short duration of action, and produces little sedative effects or physical dependence.[1]
References
- ↑ Mirza NR, Nielsen EØ. Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice? Journal of Pharmacology and Experimental Therapeutics. 2006 Mar;316(3):1378-85. PMID 16352707
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