DAA-1106

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DAA-1106
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Systematic (IUPAC) name
N-(2-phenoxy-5-fluorophenyl)-N-(2,5-dimethoxybenzyl)acetamide
Identifiers
CAS Number 220551-92-8
PubChem CID 10430788
Chemical data
Formula C23H22FNO4
Molar mass 395.423 g/mol[[Script error: No such module "String".]]
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DAA-1106 is a drug which acts as a potent and selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO, but with no affinity at central benzodiazepine receptors. It has anxiolytic effects in animal studies.[1][2][3] DAA-1106 has a sub-nanomolar binding affinity (Ki) of 0.28nM, and has been used extensively in its 3H or 11C radiolabelled form to map TSPO in the body and brain, which has proved especially helpful in monitoring the progress of neurodegenerative diseases such as Alzheimer's disease.[4][5][6][7][8][9]


References

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  1. Okuyama S, Chaki S, Yoshikawa R, Ogawa S, Suzuki Y, Okubo T, Nakazato A, Nagamine M, Tomisawa K (1999). "Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106". Life Sciences. 64 (16): 1455–64. doi:10.1016/S0024-3205(99)00079-X. PMID 10321725. 
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  3. James ML, Selleri S, Kassiou M (2006). "Development of ligands for the peripheral benzodiazepine receptor". Current Medicinal Chemistry. 13 (17): 1991–2001. doi:10.2174/092986706777584979. PMID 16842193. 
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  7. Doorduin J, de Vries EF, Dierckx RA, Klein HC (2008). "PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders". Current Pharmaceutical Design. 14 (31): 3297–315. doi:10.2174/138161208786549443. PMID 19075709. 
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