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Systematic (IUPAC) name
Clinical data
Routes of
Legal status
Legal status
  • ℞ (Prescription only)
CAS Number 20326-12-9
20344-15-4 (hydrochloride)
ATC code none
PubChem CID 71897
ChemSpider 64909
Synonyms PAP, EMD-16,923, H-4,007
Chemical data
Formula C16H21ClN4
Molar mass 304.82 g/mol[[Script error: No such module "String".]]
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Mepiprazole (Psigodal) is a minor tranquilizer with a phenylpiperazine structure used in Spain for the treatment of anxiety neuroses.[1][2][3][4][5] It acts as a 5-HT2 and α1-adrenergic receptor antagonist,[6][7][8] and has also been shown to inhibit the reuptake and induce the release of serotonin, dopamine, and norepinephrine to varying extents.[9][8] Similarly to other phenylpiperazines like trazodone, nefazodone, and etoperidone, mepiprazole produces mCPP as an active metabolite.[10]

See also


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  1. Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. 
  2. Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. 
  3. Pöldinger W (1975). "Clinical trial of 3-methyl-5-(beta-N'-(N-m-chlorophenylpiperazino)ethyl)-pyrazole dihydrochloride (Mepiprazol) in the therapy of psychovegetative disorders". International Pharmacopsychiatry. 10 (1): 1–8. PMID 1095510. 
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  5. Saldaña Hernández OH, Hernández González J (1976). "[Psychopharmological research with EMD 16-923 in patients with different degrees of anxiety]". Neurología, Neurocirugía, Psiquiatría (in Spanish; Castilian). 17 (1): 29–33. PMID 1052713. 
  6. Cohen ML, Fuller RW, Kurz KD (1983). "Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats". Hypertension. 5 (5): 676–81. PMID 6311738. 
  7. Maj J, Sypniewska M (1980). "Central action of mepiprazole". Polish Journal of Pharmacology and Pharmacy. 32 (4): 475–84. PMID 7255266. 
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