ZK-93423

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ZK-93423
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Systematic (IUPAC) name
ethyl 4-(methoxymethyl)-6-(phenylmethoxy) -9H-pyrido[5,4-b]indole-3-carboxylate
Legal status
Legal status
  • legal
Identifiers
CAS Number 83910-44-5
ATC code none
PubChem CID 121926
Chemical data
Formula C23H22N2O4
Molar mass 390.431 g/mol[[Script error: No such module "String".]]
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ZK-93423 is an anxiolytic drug from the β-Carboline family, closely related to abecarnil.[1] It is a nonbenzodiazepine GABAA agonist which is not subtype selective and stimulates α1, α2, α3, and α5-subunit containing GABAA receptors equally.[2] It has anticonvulsant, muscle relaxant and appetite stimulating properties comparable to benzodiazepine drugs.[3][4][5][6] ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the GABAA receptor.[7][8][9][10][11][12]

See also

References

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  2. Stephens DN, Shearman GT, Kehr W (1984). "Discriminative stimulus properties of beta-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors". Psychopharmacology. 83 (3): 233–9. doi:10.1007/BF00464787. PMID 6089245. 
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  10. Sharma RC, Ojha TN, Tiwari S, Singh P (1992). "Quantitative structure-activity relationship study of some benzodiazepine-receptor ligands having inverse agonist/antagonist and agonist actions". Drug Design and Discovery. 9 (2): 135–43. PMID 1338366. 
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