Difference between revisions of "Chlormezanone"

Chlormezanone
	File:Chlormezanone.svg
Systematic (IUPAC) name
	2-(4-chlorophenyl)-3-methyl-1,1-dioxo-1,3-thiazinan-4-one
Clinical data
Routes of; administration	Oral
Legal status
Legal status	℞ (Prescription only);
Pharmacokinetic data
Biological half-life	40.5 hours
Identifiers
CAS Number	80-77-3
ATC code	M03BB02 (WHO)
PubChem	CID 2717
DrugBank	APRD00865
ChemSpider	2616
Chemical data
Formula	C11H12ClNO3S
Molar mass	273.737 g/mol[[Script error: No such module "String".]]
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Latest revision as of 10:08, 20 September 2010

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Chlormezanone (marketed under the brandname Trancopal) is a drug used as an anxiolytic and a muscle relaxant.

Its use was discontinued in many countries in 1996, due to rare but serious cases of toxic epidermal necrolysis.

Wollina U, Hipler U, Seeling A, Oelschlager H (2005). "Investigations of interactions of chlormezanone racemate and its enantiomers on human keratinocytes and human leucoytes in vitro". Skin Pharmacol Physiol. 18 (3): 132–8. doi:10.1159/000084910. PMID 15897685.
Seeling A, Oelschläger H, Rothley D (2000). "Important pharmaceutical-chemical characteristics of the central muscle relaxant chlormezanone". Pharmazie. 55 (4): 293–6. PMID 10798243.
Oelschläger H, Klinger W, Rothley D, Seeling A, Bockhard H, Hofmann B, Machts H, Riederer H, Rackur H (1998). "[Cleavage and biotransformation of the central muscle relaxant chlormezanone]". Pharmazie. 53 (9): 620–4. PMID 9770210.
Gautier V, Vincon G, Demotes-Mainard F, Albin H (1990). "[Pharmacokinetics of chlormezanone in healthy volunteers] (original in French)". Pharmazie. 45 (4): 315–9. PMID 2399514.

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