TP-13
From Self-sufficiency
Revision as of 16:22, 30 July 2010 by PotatoBot (Talk) (Stub sorting and placement of stub template(s): nervous-system-drug-stub)
| File:TP-13.png | |
| Systematic (IUPAC) name | |
|---|---|
|
7-Cyclobutyl-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-phenyl-1,2,4-triazolo[4,3-b] pyridazine | |
| Chemical data | |
| Formula | C19H19N7O |
| Molar mass | 361.400 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
TP-13 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It is a subtype-selective partial agonist at GABAA receptors, binding selectively to GABAA receptor complexes bearing α2 and α3 subunits.[1] It has modest anticonvulsant activity although less than that of diazepam,[2] and its main effect is likely to be selective anxiolytic action, as seen with other related α2/3-preferring agonists such as L-838,417.
References
- ↑ McCabe C, Shaw D, Atack JR, Street LJ, Wafford KA, Dawson GR, Reynolds DS, Leslie JC. Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour. Neuropharmacology. 2004 Feb;46(2):171-8. PMID 14680756
- ↑ Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR. Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. Journal of Psychopharmacology. 2007 Jun;21(4):384-91. PMID 17092983
| 35px | This drug article relating to the nervous system is a stub. You can help ssf by expanding it. |
Categories:
- Pages with script errors
- Pages with broken file links
- Infobox drug tracked parameters
- Chemical articles without CAS Registry Number
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugboxes with an unspecified ATC code
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Anxiolytics
- Ethers
- Triazoles
- Triazolopyridazines
- Nervous system drug stubs
- 2Fix
