Bucolome

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Revision as of 15:31, 28 May 2009 by Anypodetos (Talk) (No ATC code)

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Bucolome
Systematic (IUPAC) name
200px
5-butyl-1-cyclohexyl-1,3-diazinane-2,4,6-trione
Identifiers
CAS Number	841-73-6
ATC code	none
PubChem	CID 2461
Synonyms	Bucolome, Paramidine
Chemical data
Formula	C₁₄H₂₂N₂O₃
Molar mass	224.256 g/mol[[Script error: No such module "String".]]
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Bucolome (Paramidine) is a barbiturate derivative. Unlike most barbiturates it does not have any significant sedative or hypnotic effects, but instead acts as an analgesic and antiinflammatory. It also acts as a CYP2C9 inhibitor and reduces the metabolism of several commonly used drugs, which makes it useful for potentiating or extending the duration of action of those drugs, or reducing the production of unwanted metabolites.^[1]^[2]^[3]

References

↑ Takamura N, Maruyama T, Chosa E, Kawai K, Tsutsumi Y, Uryu Y, Yamasaki K, Deguchi T, Otagiri M. Bucolome, a potent binding inhibitor for furosemide, alters the pharmacokinetics and diuretic effect of furosemide: potential for use of bucolome to restore diuretic response in nephrotic syndrome. Drug Metabolism and Disposition. 2005 Apr;33(4):596-602. PMID 15640375
↑ Osawa M, Hada N, Matsumoto K, Hasegawa T, Kobayashi D, Morimoto Y, Yamaguchi M, Kanamoto I, Nakagawa T, Sugibayashi K. Usefulness of coadministration of bucolome in warfarin therapy: pharmacokinetic and pharmacodynamic analysis using outpatient prescriptions. International Journal of Pharmaceutics. 2005 Apr 11;293(1-2):43-9. PMID 15778043
↑ Kobayashi M, Takagi M, Fukumoto K, Kato R, Tanaka K, Ueno K. The effect of bucolome, a CYP2C9 inhibitor, on the pharmacokinetics of losartan. Drug Metabolism and Pharmacokinetics. 2008;23(2):115-9. PMID 18445991

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v t e GABA_A receptor positive allosteric modulators
Barbiturates	Allobarbital • Alphenal • Amobarbital • Aprobarbital • Barbexaclone • Barbital • Benzobarbital • Benzylbutylbarbiturate • Brallobarbital • Brophebarbital • Bucolome • Butabarbital • Butalbital • Butobarbital • Butallylonal • Carbubarb • Crotylbarbital • Cyclobarbital • Cyclopal • Enallylpropymal • Ethallobarbital • Febarbamate • Heptabarbital • Hexethal • Hexobarbital • Mephobarbital • Metharbital • Methohexital • Methylphenobarbital • Narcobarbital • Nealbarbital • Pentobarbital • Phenobarbital • Phetharbital • Primidone • Prazitone • Probarbital • Propallylonal • Proxibarbal • Proxibarbital • Reposal • Secbutabarbital • Secobarbital • Sigmodal • Spirobarbital • Talbutal • Thialbarbital • Thiamylal • Thiobarbital • Thiobutabarbital • Thiopental • Valofane • Vinbarbital • Vinylbital
Benzodiazepines	Adinazolam • Alprazolam • Arfendazam • Avizafone • Bentazepam • Bretazenil • Bromazepam • Brotizolam • Camazepam • Chlordiazepoxide • Ciclotizolam • Cinolazepam • Clazolam • Climazolam • Clobazam • Clonazepam • Clorazepate • Clotiazepam • Cloxazolam • Cyprazepam • Delorazepam • Diazepam • Doxefazepam • Elfazepam • Estazolam • Ethyl carfluzepate • Ethyl dirazepate • Ethyl loflazepate • Etizolam • Fletazepam • Fludiazepam • Flunitrazepam • Flurazepam • Flutazolam • Flutemazepam • Flutoprazepam • Fosazepam • Gidazepam • Girisopam • Halazepam • Haloxazolam • Iclazepam • Imidazenil • Ketazolam • Lofendazam • Lopirazepam • Lopirazepam • Loprazolam • Lorazepam • Lormetazepam • Meclonazepam • Medazepam • Menitrazepam • Metaclazepam • Mexazolam • Midazolam • Nerisopam • Nimetazepam • Nitrazepam • Nitrazepate • Nordazepam • Oxazepam • Oxazolam • Phenazepam • Pinazepam • Pivoxazepam • Prazepam • Premazepam • Proflazepam • QH-II-66 • Quazepam • Reclazepam • Remimazolam • Rilmazafone • Ripazepam • Ro48-6791 • SH-053-R-CH3-2′F • Sulazepam • Temazepam • Tetrazepam • Tofisopam • Triazolam • Triflubazam • Uldazepam • Zapizolam • Zolazepam • Zomebazam
Carbamates	Carisbamate • Carisoprodol • Emylcamate • Ethinamate • Febarbamate • Felbamate • Hexapropymate • Mebutamate • Meprobamate • Methocarbamol • Phenprobamate • Procymate • Styramate • Tybamate
Neuroactive steroids	Acebrochol • Allopregnanolone • Alphadolone • Alphaxolone • Ganaxolone • Hydroxydione • Minaxolone • Org 20599 • THDOC
Nonbenzodiazepines	Abecarnil • Adipiplon • Alpidem • CGS-20625 • CGS-9896 • CL-218,872 • ELB-139 • Eszopiclone • Fasiplon • Gedocarnil • Indiplon • L-838,417 • Necopidem • NS-2664 • NS-2710 • Ocinaplon • Pagoclone • Panadiplon • Pazinaclone • Pipequaline • ROD-188 • RWJ-51204 • Saripidem • SB-205,384 • SL-651,498 • Suproclone • Suriclone • SX-3228 • Taniplon • TP-003 • TPA-023 • TP-13 • U-89843A • U-90042 • Y-23684 • Zaleplon • Zolpidem • Zopiclone
Phenols	Fospropofol • Propofol • Thymol
Piperidinediones	Glutethimide • Methyprylon • Piperidione • Pyrithyldione
Pyrazolopyridines	Cartazolate • Etazolate • ICI-190,622 • Tracazolate
Quinazolinones	Afloqualone • Cloroqualone • Diproqualone • Etaqualone • Mebroqualone • Mecloqualone • Methaqualone • Methylmethaqualone
Volatiles/gases	2-Methyl-2-butanol • Acetone • Acetophenone • Acetylglycinamide chloral hydrate • Benzene • Butane • Butanol • Butylene • Centalun • Chloral • Chloral hydrate • Chlorobutanol • Chloroform • Cyclopropane • Desflurane • Dichloromethane • Diethyl ether • Enflurane • Ethanol (Alcohol) • Ethyl chloride • Ethylene • Gasoline • Halothane • Isoflurane • Kerosine • Menthol • Methanol • Methoxyflurane • Methoxypropane • Methylbutanol • Nitric oxide • Nitrogen • Nitrous oxide • Paraldehyde • Pentanol • Propane • Propanol • Propylene • Sevoflurane • Toluene • Trichloroethanol • Trichloroethylene • Vinyl ether • Xenon
Others	Bromide (Lithium bromide, Potassium bromide, Sodium bromide) • Chloralodol • Chloralose • Chlormezanone • Clomethiazole • DEABL • Ethchlorvynol • Etifoxine • Etomidate • GABA • Kavalactones (Kava-kava) • Loreclezole • Methylpentynol • Petrichloral • Propanidid • Skullcap • Stiripentol • Sulfonmethane • Tetronal • Triclofos • Trional • Valeric acid, Valerenic acid (Valerian)

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