VUF-6002

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VUF-6002
File:VUF-6002.png
Systematic (IUPAC) name
5-Chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-benzimidazole
Identifiers
CAS Number 869497-75-6
PubChem CID 10446295
IUPHAR/BPS 1277
Chemical data
Formula C13H15ClN4O
Molar mass 278.737 g/mol[[Script error: No such module "String".]]
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VUF-6002 (JNJ 10191584) is a drug which acts as a potent and selective antagonist at the histamine H4 receptor.[1] It has antiinflammatory and analgesic effects in animal studies of acute inflammation.[2]

References

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  1. ↑ Zhang M, Thurmond RL, Dunford PJ. The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders. Pharmacology and Therapeutics. 2007 Mar;113(3):594-606. PMID 17275092
  2. ↑ Coruzzi G, Adami M, Guaita E, de Esch IJ, Leurs R. Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation. European Journal of Pharmacology. 2007 Jun 1;563(1-3):240-4. PMID 17382315
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