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Systematic (IUPAC) name
(S)-N-tert-butyl- 3-(4-(2-methoxyphenyl)- piperazin-1-yl)- 2-phenylpropanamide
CAS Number 133025-23-7
PubChem CID 115111
Chemical data
Formula C24H33N3O2
Molar mass 395.536 g/mol[[Script error: No such module "String".]]
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WAY-100,135 is a piperazine drug and research chemical used in scientific studies. It was originally believed to act as a selective 5-HT1A receptor antagonist, but subsequent research demonstrated that it also acts as a partial agonist at the 5-HT1B and 5-HT1D receptors.[1][2]

See also


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  1. Cliffe IA, Brightwell CI, Fletcher A, Forster EA, Mansell HL, Reilly Y, Routledge C, White AC. (1993). "(S)-N-tert-butyl- 3-(4-(2-methoxyphenyl)- piperazin-1-yl)- 2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors". J Med Chem. 36 (10): 1509–1510. doi:10.1021/jm00062a028. PMID 8496920. 
  2. Davidson C, Ho M, Price GW, Jones BJ, Stamford JA. (1997). "(+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors". Br J Pharmacol. 121 (4): 737–742. doi:10.1038/sj.bjp.0701197. PMC 1564750Freely accessible. PMID 9208142.