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Systematic (IUPAC) name
CAS Number 402713-80-8
PubChem CID 6918649
Chemical data
Formula C18H21Cl2N3O4S
Molar mass 446.347 g/mol[[Script error: No such module "String".]]
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SB-399885 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT6 receptor antagonist, with a Ki of 9.0nM. SB-399885 and other 5-HT6 antagonists show nootropic effects in animal studies,[1][2] as well as antidepressant and anxiolytic effects which are comparable to and synergistic with drugs such as imipramine and diazepam,[3][4][5] and have been proposed as potential novel treatments for cognitive disorders such as schizophrenia[6] and Alzheimer's disease.


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  1. Perez-García G, Meneses A. Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task. Pharmacology, Biochemistry and Behaviour. 2005 Jul;81(3):673-82. PMID: 15964617
  2. Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. European Journal of Pharmacology. 2006 Dec 28;553(1-3):109-19. PMID 17069795
  3. Wesołowska A, Nikiforuk A. Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology. 2007 Apr;52(5):1274-83. PMID 17320917
  4. Wesołowska A. The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors. European Journal of Pharmacology. 2008 Feb 12;580(3):355-60. PMID 18096153
  5. Wesołowska A, Nikiforuk A. The selective 5-HT(6) receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats. European Journal of Pharmacology. 2008 Mar 17;582(1-3):88-93. PMID 18234190
  6. Li Z, Huang M, Prus AJ, Dai J, Meltzer HY. 5-HT6 receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus. Brain Research. 2007 Feb 23;1134(1):70-8. PMID 17207474