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Systematic (IUPAC) name
Clinical data
Routes of
Legal status
Legal status
  • Uncontrolled
Pharmacokinetic data
Biological half-life 1-4 hours
CAS Number 114298-18-9
ATC code none
PubChem CID 163925
Chemical data
Formula C24H29N5O2
Molar mass 419.519 g/mol[[Script error: No such module "String".]]
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Zalospirone (WY-47,846) is a selective 5-HT1A partial agonist of the azapirone chemical class.[1][2] It was found to be effective in the treatment of anxiety and depression in clinical trials, but a high proportion of subjects dropped out due to side effects and development was subsequently never completed.[3]

See also


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  1. Gleeson S, Barrett JE. 5-HT1A agonist effects on punished responding of squirrel monkeys. Pharmacology, Biochemistry and Behaviour. 1990 Oct;37(2):335-7. PMID 1981937
  2. Singh A, Lucki I. Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors. Neuropharmacology. 1993 Apr;32(4):331-40. PMID 8497336
  3. Rickels K, Derivan A, Kunz N, Pallay A, Schweizer E. Zalospirone in major depression: a placebo-controlled multicenter study. Journal of Clinical Psychopharmacology. 1996 Jun;16(3):212-7. PMID 8784652