Clopenthixol

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Clopenthixol
File:Clopenthixol Structural Formulae.png
Systematic (IUPAC) name
cis,trans-2-[4-[3-(2-chlorothioxanthen-9-ylidene) propyl]piperazin-1-yl]ethanol
Clinical data
Routes of
administration
Oral
Identifiers
CAS Number 982-24-1
ATC code N05AF02 (WHO)
PubChem CID 12454
ChemSpider 11945
Chemical data
Formula C22H25ClN2OS
Molar mass 400.965 g/mol[[Script error: No such module "String".]]
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Clopenthixol (Sordinol), also known as clopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced by Lundbeck in 1961.[1]

Clopenthixol is a racemic mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, was later introduced by Lundbeck in 1962,[2] and has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.[3]

See also

References

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External links



de:Clopenthixol

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  1. Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1.  More than one of |pages= and |page= specified (help)
  2. José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 516. ISBN 3-527-31058-4.  More than one of |pages= and |page= specified (help)
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