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File:7-PET structure.png
Systematic (IUPAC) name
CAS Number 13965-63-4
PubChem CID 203125
Chemical data
Formula C31H39NO4
Molar mass 487.64 g/mol[[Script error: No such module "String".]]
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7-PET is a potent analgesic drug, 300 times the potency of morphine by weight.[1] It is related to the more well-known oripavine derivative opioid etorphine, which is used as a very potent veterinary painkiller and anesthetic medication, used primarily for the sedation of large animals such as elephants, giraffes and rhinos. 7-PET itself has a 3-O-methyl ether which reduces potency, but the 3-OH derivative is around 2200x morphine, almost the same potency as etorphine as a μ agonist,[2][3] and unexpectedly the 3-desoxy compound is also around the same potency of 2000x morphine.[4]

Unlike etorphine however, 7-PET is not an illegal drug, and is not controlled under the UN drug conventions, but it might still be considered to be a controlled substance analogue of etorphine on the grounds of its related chemical structure in some jurisdictions such as the USA, Canada, Australia and New Zealand.

See also


  1. Lewis JW, Bentley KW, Cowan A. Narcotic Analgesics and Antagonists. Annual Reviews in Pharmacology 1971;11:241-270.
  2. Feinberg AP, Creese I, Snyder SH. The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists. Proceedings of the National Academy of Sciences U S A. 1976 Nov;73(11):4215-9.
  3. Bentley KW, Lewis JW. Agonist and Antagonist Actions of Narcotic Analgesic Drugs. pp 7-16. University Park Press, Baltimore. (1973)
  4. Lewis, J. W.; Readhead, M. J. (1970). "Novel analgetics and molecular rearrangements in the morphine-thebaine group. XVIII. 3-Deoxy-6,14-endo-etheno-6,7,8,14-tetrahydrooripavines". Journal of Medicinal Chemistry. 13 (3): 525. doi:10.1021/jm00297a041. PMID 5441135.  edit