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style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers
CAS number 63631-40-3
PubChem 6917707
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style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula C29H39N5O7
Molar mass 569.65 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

DADLE ([D-Ala2, D-Leu5]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective delta opioid receptor agonist, it also binds to the μ1 subtype of mu opioid receptors.

Treatment with DADLE results in transient depression of mean arterial blood pressure and heart rate.[1][2]

Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.


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  1. Medical Dictionary Online
  2. Online Medical Dictionary, enkephalin, leucine-2-alanine