Chloromorphide

Chloromorphide

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Systematic (IUPAC) name
3-hydroxy- 6α-chloro- 7,8-didehydro- 4,5α-epoxy- 17-methylmorphinan
Identifiers
ATC code	none
PubChem	CID 5745724
Synonyms	α-Chloromorphide
Chemical data
Formula	C17H18ClNO2
Molar mass	303.78 g/mol[[]]

Chloromorphide (α-Chloromorphide) is an opiate analogue that is a derivative of morphine, where the 6-hydroxy group has been replaced by chlorine. Developed in 1933 in Germany, it has approximately ten times the potency of morphine. It has similar effects to morphine such as sedation, analgesia and respiratory depression.

Chloromorphide is one of a series of opioids known as morphides and codides which are important precursors and intermediates in the synthesis of semi-synthetic opioid analgesic drugs, especially those with additions, substitutions, or other modifications at the 7, 8, and/or 14 position on the morphine carbon skeleton; semisynthetics with changes at other positions can also be made from these compounds. The codeine analogue of chloromorphide is alphachlorcodide (α-chlorocodide), an intermediate in one method of desomorphine sythesis which uses codeine as precursor.