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Systematic (IUPAC) name
3-hydroxy- 6α-chloro- 7,8-didehydro- 4,5α-epoxy- 17-methylmorphinan
ATC code none
PubChem CID 5745724
Synonyms α-Chloromorphide
Chemical data
Formula C17H18ClNO2
Molar mass 303.78 g/mol[[Script error: No such module "String".]]
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Chloromorphide (α-Chloromorphide) is an opiate analogue that is a derivative of morphine, where the 6-hydroxy group has been replaced by chlorine. Developed in 1933 in Germany, it has approximately ten times the potency of morphine.[1] It has similar effects to morphine such as sedation, analgesia and respiratory depression.

Chloromorphide is one of a series of opioids known as morphides and codides which are important precursors and intermediates in the synthesis of semi-synthetic opioid analgesic drugs, especially those with additions, substitutions, or other modifications at the 7, 8, and/or 14 position on the morphine carbon skeleton; semisynthetics with changes at other positions can also be made from these compounds. The codeine analogue of chloromorphide is alphachlorcodide (α-chlorocodide), an intermediate in one method of desomorphine sythesis which uses codeine as precursor.


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  1. Yeh HJC, Wilson RS, Klee WA, Jacobson AE. J Pharm Sci 1976; 65: 902.